CAJ | 학술논문

目的研究胰岛素样生长因子Ⅱ(IGF-Ⅱ)、碱性成纤维细胞生长因子(bFGF)及其受体(IGF-1R和FGFR2)在巨指患者受累组织内的表达情况,探索巨指的发病机理及神经组织与巨指发生、发展的关系.方法对15例巨指病理组织进行组织学和免疫组化染色及半定量分析,并与15例对照组织(多指组织)进行比较.结果 15例巨指组织均有神经受累增粗,组织学检查符合神经纤维脂肪性错构瘤表现.巨指组织中IGF-Ⅱ、bFGF及其受体IGF-1R和FGFR2的表达均高于对照组织,差异有统计学意义.巨指标本中,IGF-Ⅱ、bFGF和IGF-1R在雪旺细胞和神经轴索中的表达均高于脂肪和纤维组织,差异有统计学意义,而FGFR2的表达差异无统计学意义.结论巨指受累组织中IGF-Ⅱ、bFGF及其受体有高表达,而且这两种生长因子在外周神经组织中的表达较增生的脂肪、纤维组织高.
목적 연구이도소양생장인자Ⅱ(IGF-Ⅱ)、감성성섬유세포생장인자(bFGF)급기수체(IGF-1R화FGFR2)재거지환자수루조직내적표체정황,탐색거지적발병궤리급신경조직여거지발생、발전적관계.방법 대15례거지병리조직진행조직학화면역조화염색급반정량분석,병여15례대조조직(다지조직)진행비교.결과 15례거지조직균유신경수루증조,조직학검사부합신경섬유지방성착구류표현.거지조직중IGF-Ⅱ、bFGF급기수체IGF-1R화FGFR2적표체균고우대조조직,차이유통계학의의.거지표본중,IGF-Ⅱ、bFGF화IGF-1R재설왕세포화신경축색중적표체균고우지방화섬유조직,차이유통계학의의,이FGFR2적표체차이무통계학의의.결론 거지수루조직중IGF-Ⅱ、bFGF급기수체유고표체,이차저량충생장인자재외주신경조직중적표체교증생적지방、섬유조직고.
Objective To examine the expression of insulin-like growth factor Ⅱ (IGF-Ⅱ ), basic fibroblast growth factor (bFGF) and their receptors ( IGF-1R and FGFR2 ) in affected tissue of macrodactyly,and to analyze the pathogenesis of macrodactyly and the involvement of nerves. Methods Tissues that were resected from 15 cases of macrodactyly underwent histological and immunohistochemical analysis to semi-quantitatively analyze the expression of IGF-Ⅱ , bFGF, IGF-1R and FGFR2. Tissues obtained from resection of polydactyly underwent the same processing and served as control. Results Nerve involvement was seen in all the 15 eases. The nerves were thickened and histological examination showed pathology pertinent to fibrolipomatous hamartoma of nerve. When compared with control tissues, the expression of IGF-Ⅱ , bFGF, IGF-1R and FGFR2 was significantly increased in macroactyly tissues. Schwann ceils and axons in the macrodactyly tissue demonstrated significantly higher expression of IGF-Ⅱ, bFGF and IGF-1R than the fat and fibrous tissue, whereas expression of FGFR2 was not statistically different. Conclusion There is increased expression of IGF-Ⅱ , bFGF and their receptors in affected tissue of macrodactyly. In addition, there is distinctly higher expression of these two growth factors in peripheral nerves than in other tissues.