中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2009年
6期
30-32,35
,共4页
张映仁%刘长友%李平球%胡鹏%吴刚%李文莲%陈凡平%张士成
張映仁%劉長友%李平毬%鬍鵬%吳剛%李文蓮%陳凡平%張士成
장영인%류장우%리평구%호붕%오강%리문련%진범평%장사성
链霉素%静脉滴注%肺结核
鏈黴素%靜脈滴註%肺結覈
련매소%정맥적주%폐결핵
Streptomycin%Intravenous drop%Tuberculosis,Lung
目的 探讨肺结核短程化疗方案中链霉素静脉滴注与肌肉注射两种不同用药途径对肺结核治疗效果及不良反应的影响.方法 对289例初治茵阳的住院肺结核病人,按入院顺序随机分为链霉素静脉滴注组与肌肉注射组进行观察.结果 静脉滴注组病人痰茵阴转平均天数(29±18)d短于肌肉注射组(33±22)d、胸部X线病灶吸收及空洞闭合疗效构成比静脉滴注组高于肌肉注射组,但以上情况两组对比差异均无统计学意义(P＞0.05).肝肾功能损害及耳毒性两组对比差异无统计学意义(P＞0.05).病人对所采用注射方法的满意度静脉滴注组明显高于肌肉注射组,两组对比差异有统计学意义(u=2.09,P＜0.05).结论 链霉素静脉滴注,可有效减轻病人因肌肉注射引起的疼痛和局部不良反应,提高痰茵阴转率,缩短了空洞闭合时间,毒副作用未见增加,为本药的应用提供了新的用药途径.
目的 探討肺結覈短程化療方案中鏈黴素靜脈滴註與肌肉註射兩種不同用藥途徑對肺結覈治療效果及不良反應的影響.方法 對289例初治茵暘的住院肺結覈病人,按入院順序隨機分為鏈黴素靜脈滴註組與肌肉註射組進行觀察.結果 靜脈滴註組病人痰茵陰轉平均天數(29±18)d短于肌肉註射組(33±22)d、胸部X線病竈吸收及空洞閉閤療效構成比靜脈滴註組高于肌肉註射組,但以上情況兩組對比差異均無統計學意義(P＞0.05).肝腎功能損害及耳毒性兩組對比差異無統計學意義(P＞0.05).病人對所採用註射方法的滿意度靜脈滴註組明顯高于肌肉註射組,兩組對比差異有統計學意義(u=2.09,P＜0.05).結論 鏈黴素靜脈滴註,可有效減輕病人因肌肉註射引起的疼痛和跼部不良反應,提高痰茵陰轉率,縮短瞭空洞閉閤時間,毒副作用未見增加,為本藥的應用提供瞭新的用藥途徑.
목적 탐토폐결핵단정화료방안중련매소정맥적주여기육주사량충불동용약도경대폐결핵치료효과급불량반응적영향.방법 대289례초치인양적주원폐결핵병인,안입원순서수궤분위련매소정맥적주조여기육주사조진행관찰.결과 정맥적주조병인담인음전평균천수(29±18)d단우기육주사조(33±22)d、흉부X선병조흡수급공동폐합료효구성비정맥적주조고우기육주사조,단이상정황량조대비차이균무통계학의의(P＞0.05).간신공능손해급이독성량조대비차이무통계학의의(P＞0.05).병인대소채용주사방법적만의도정맥적주조명현고우기육주사조,량조대비차이유통계학의의(u=2.09,P＜0.05).결론 련매소정맥적주,가유효감경병인인기육주사인기적동통화국부불량반응,제고담인음전솔,축단료공동폐합시간,독부작용미견증가,위본약적응용제공료신적용약도경.
Objective To explore influence of effect and side-effects for tuberculosis we took two different ways of using intravenous streptomycin drop and intramuscular injection in PTB shortcourse chemotherapy.Methods 289 cases of inpatients with PTB showing positive sputum were divided into two groups according to the order admitted into the hospital and randomly,one treated with streptomycin intravenous drop and the other with intramuscular.Results The average days of sputum negative conversion in intravenous drop group(28 ± 18)d were shorter than in intramuscular group(33 ±22),and the ratio of X-ray nidus absorption and cavity occlusion in intravenous drop group was higher than in intramuscular group,but the above mentioned,there were no remarkable difference between two groups (P＞0.05).There were no remarkable difference in hepat-kidney function lesion(P＞0.05),and there were no any difference about oto-toxicity on two groups(P＞0.05).The patients in intravenous drop group are more content than in intramuscular group,and there was remarkable difference in two groups(u =2.09 P＜0.05).Conclusions Intravenous streptomycin can deliver the patients' pain and local side-effects resulting from injection,increase the sputum negative conversion,shorten the time of cavity occlusion.Toxico-side effect has no been found increasing.So the application of this medicine supplies is a new way for it.
