SLC22A4和RUNX1基因的单核苷酸多态性与中国汉族类风湿性关节炎和强直性关节炎的关联分析
SLC22A4화RUNX1기인적단핵감산다태성여중국한족류풍습성관절염화강직성관절염적관련분석
Association between single nucleotide polymorphisms of SLC22A4 and RUNX1 gene with rheumatoid arthritis and ankylosing spondylitis in Chinese Han ethnicity
  • 万方数据
    第二军医大学学报 제이군의대학학보
    ACADEMIC JOURNAL OF SECOND MILITARY MEDICAL UNIVERSITY
    2007年 9期 936-940 ,共5页

    程宁%陈蕊雯%蔡青%段世伟%房萌%郑桂敏%王智华%林经安%孙树汉

    정저%진예문%채청%단세위%방맹%정계민%왕지화%림경안%손수한

    类风湿性关节炎%强直性脊柱炎%多态性,单核苷酸%SLC22A4%RUNX1 類風濕性關節炎%彊直性脊柱炎%多態性,單覈苷痠%SLC22A4%RUNX1
    류풍습성관절염%강직성척주염%다태성,단핵감산%SLC22A4%RUNX1
    目的:在中国汉族人群中进行功能候选基因SLC22A4(solute carrier family 22 member 4)和RUNX1(runt-related transcription factor 1)与类风湿性关节炎(rheumatoid arthritis, RA)以及强直性脊柱炎 (ankylosing spondylitis, AS)的关联分析.方法:在104例RA患者和109名正常对照以及278 例AS患者和417名正常对照中,用直接测序法对SLC22A4的3个单核苷酸多态性(single nucleotide polymorphism, SNP)位点和RUNX1的1个SNP进行基因分型,并分析这些等位基因和基因型是否与RA和AS的发病有关.结果:在RA 和 AS 病例-对照组中均没有发现SLC22A4和RUNX1的SNPs在等位基因以及基因型频率上有显著性差异.结论:在中国汉族人群中,SLC22A4和RUNX1不是RA和 AS 的易感基因.
    목적:재중국한족인군중진행공능후선기인SLC22A4(solute carrier family 22 member 4)화RUNX1(runt-related transcription factor 1)여류풍습성관절염(rheumatoid arthritis, RA)이급강직성척주염 (ankylosing spondylitis, AS)적관련분석.방법:재104례RA환자화109명정상대조이급278 례AS환자화417명정상대조중,용직접측서법대SLC22A4적3개단핵감산다태성(single nucleotide polymorphism, SNP)위점화RUNX1적1개SNP진행기인분형,병분석저사등위기인화기인형시부여RA화AS적발병유관.결과:재RA 화 AS 병례-대조조중균몰유발현SLC22A4화RUNX1적SNPs재등위기인이급기인형빈솔상유현저성차이.결론:재중국한족인군중,SLC22A4화RUNX1불시RA화 AS 적역감기인.
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