CAJ | 학술논문

目的:观察黄蜀葵对实验性大鼠血清睾酮(T)、雌二醇(E2)、T/E2的调节作用及对毛发脱落的影响.方法:采用大鼠颈后皮下注射5 mg/(kg·d)剂量的丙酸睾丸酮造成脂脱模型,同时对实验组用黄蜀葵油煎剂进行治疗,并用山茶油作溶剂对照组,每天观察脱毛实验观察区脱毛情况,连续给药60 d后取血,用放射免疫法检测各组动物血清T、E2并计算出T/E2.结果:与正常对照组比较,模型组和溶剂对照组大鼠血清T明显升高,T/E2明显升高,单位面积脱毛数量明显增高(P<0.01);黄蜀葵油煎剂组分别与模型组、溶剂对照组比较,血清T明显降低,T/E2降低,单位面积脱毛数量减少(P<0.01).结论:脂脱大鼠体内存在着明显的性激素(尤其是雄激素)失调,黄蜀葵可调节机体的性激素水平,使紊乱的T/E2趋于正常,预防毛发脱落.
목적:관찰황촉규대실험성대서혈청고동(T)、자이순(E2)、T/E2적조절작용급대모발탈락적영향.방법:채용대서경후피하주사5 mg/(kg·d)제량적병산고환동조성지탈모형,동시대실험조용황촉규유전제진행치료,병용산다유작용제대조조,매천관찰탈모실험관찰구탈모정황,련속급약60 d후취혈,용방사면역법검측각조동물혈청T、E2병계산출T/E2.결과:여정상대조조비교,모형조화용제대조조대서혈청T명현승고,T/E2명현승고,단위면적탈모수량명현증고(P<0.01);황촉규유전제조분별여모형조、용제대조조비교,혈청T명현강저,T/E2강저,단위면적탈모수량감소(P<0.01).결론:지탈대서체내존재착명현적성격소(우기시웅격소)실조,황촉규가조절궤체적성격소수평,사문란적T/E2추우정상,예방모발탈락.
Objective:To investigate the regulation of Abelmoschus manihot on testosterone (T),estradiol(E2) and the proportion of T to E2 (T/E2) in rats blood and effect of losing hair.Methods:Seborrheic alopecia model was established by subcutaneous injection of T(5mg/kg·d),Smearing Abelmoschus manihot(2ml/d in the prophase,1 ml/d in the second half phase) in the same time continuously for 60 days.Use camellia oil as solvent control group.T,E2 and T/E2 groups were detected by radioimmtmoassay(RIA) method.Results:As compared with the normal group,the levels of T and T/E2 were higher.As compared with model group and solvent control group,the levels of T and T/E2 were lower in treated group.Conclusion:There is an obvious imbalance of sex hormones (apecially androgenic hormones) in seborrheic alopecia.Abelmoschus manihot has the contraction of alopecin of hair.It can make the T/E2 to be stable.