CAJ | 학술논문

目的探讨CFC方案时辰化疗治疗颌面部鳞癌的疗效及毒副反应.方法 15例颌面部鳞癌患者,采用CFC方案时辰化疗[卡铂(CBP)、5-氟尿嘧啶(5-Fu)、甲酰四氢叶酸钙(CF)],给药时间在16:00至次日7:00,观察CFC方案化疗患者的疗效及毒副作用,化疗后10 ～ 21 d手术.结果 CFC方案时辰化疗后,完全缓解(CR)为3例,术后病理检查原发癌已查不到癌细胞,部分缓解(PR)为11例,无效(NR)为1例,总有效率(CR + PR)为93.3%;而出现的毒副作用仅为轻度的疲倦、恶心、呕吐,以及WBC与RBC降低.结论 CFC方案疗效确切,时辰化疗可明显减少患者化疗药物的毒副反应,值得临床推广应用.
목적 탐토CFC방안시신화료치료합면부린암적료효급독부반응.방법 15례합면부린암환자,채용CFC방안시신화료[잡박(CBP)、5-불뇨밀정(5-Fu)、갑선사경협산개(CF)],급약시간재16:00지차일7:00,관찰CFC방안화료환자적료효급독부작용,화료후10 ～ 21 d수술.결과 CFC방안시신화료후,완전완해(CR)위3례,술후병리검사원발암이사불도암세포,부분완해(PR)위11례,무효(NR)위1례,총유효솔(CR + PR)위93.3%;이출현적독부작용부위경도적피권、악심、구토,이급WBC여RBC강저.결론 CFC방안료효학절,시신화료가명현감소환자화료약물적독부반응,치득림상추엄응용.
Objective To evaluate therapeutic effect and toxic recation of CFC regimen chrono-chemotherapy in the treatment of maxillofacial squamous cell carcinoma. Methods 15 cases of maxillofacial squamous cell carcinoma were all treated by the CFC medicine project(Carboplatin; 5-Fluorouracil; Calcium Folinate). The Chrono-chemotherapy medicine was administrated from 16:00 to tomorrow 7:00. Therapeutic effect and toxicities were observed. The operation was performed in 10 ～ 21 days after chemotherapy. Results After chemotherapy, complete response (CR) was achieved in 3 case, partial response (PR) in 11 cases and no nesponse (NR) in 1 case. The overall response rate (CR+PR) was 93.3%. the Chrono-chemotherapy medicine has lower toxicities incidence rate, such as nausea, vomiting, descending WBC and RBC. Conclusion Chrono-chemotherapy, which has lower toxicities incidence, was potentially recommended for clinical application.