CAJ | 학술논문

华法林是最常应用的口服抗凝药之一.近年来关于华法林个体化用药的最大的研究进展是基于基因多态性的给药模型,以及大规模的随机对照临床试验用于评价给药模型的有效性和安全性.本文综述了与华法林剂量需求相关的药效学及药代动力学基因多态性;同时,介绍了基于基因多态性的华法林给药模型的最新进展,为临床华法林个体化用药提供参考.
화법림시최상응용적구복항응약지일.근년래관우화법림개체화용약적최대적연구진전시기우기인다태성적급약모형,이급대규모적수궤대조림상시험용우평개급약모형적유효성화안전성.본문종술료여화법림제량수구상관적약효학급약대동역학기인다태성;동시,개소료기우기인다태성적화법림급약모형적최신진전,위림상화법림개체화용약제공삼고.
farin is one of the most usually prescribed oral anticoagu-lation. A large number of studies investigated on the relationship between gene polymorphisms and warfarin dosage requirement. Recently, gene -guided warfarin dose regimens were fully investigated, and some random?ized controlled clinical trials were designed to evaluate the safety and efficacy of gene - guided regimens. This article reviewed warfarin - dosage -related pharmacokinetics and pharmacodynamics gene polymorphisms, and introduced the newly published studies on dosing regimens, in order to supply some suggestion for warfarin individual dosage.