中国急救医学
中國急救醫學
중국급구의학
CHINESE JOURNAL OF CRITICAL CARE MEDICINE
2010年
4期
345-347
,共3页
氨基末端-脑钠肽前体(NT-proBNP)%急性冠脉综合征(ACS)%诊断
氨基末耑-腦鈉肽前體(NT-proBNP)%急性冠脈綜閤徵(ACS)%診斷
안기말단-뇌납태전체(NT-proBNP)%급성관맥종합정(ACS)%진단
N-terminal pro-brain natriuretic peptide(NT-proBNP)%Acute coronary syndrome%Diagnosis
目的 探讨急性冠脉综合征(ACS)患者早期氨基末端-脑钠肽前体(N-terminal pro-brain natriuretic peptide,NT-proBNP)浓度的变化及其临床意义.方法 选取健康体检者15 例,稳定型心绞痛(SAP)患者15 例,ACS早期患者60 例[其中急性心肌梗死(AMI)组35例,不稳定型心绞痛(UA)组25 例].采用电化学发光免疫法(ECLIA)测定血浆NT-proBNP浓度.结果 与健康对照组NT-proBNP比较,ACS患者血浆NT-proBNP浓度明显升高(P<0.01),且AMI组NT-proBNP浓度[(1900.10±571.15)pg/mL]高于UA组[(312.78±44.47)pg/mL,P<0.01],SAP组与对照组比较差异无统计学意义.结论 血浆NT-proBNP浓度检测可为ACS早期诊断提供非常有价值的参考依据.
目的 探討急性冠脈綜閤徵(ACS)患者早期氨基末耑-腦鈉肽前體(N-terminal pro-brain natriuretic peptide,NT-proBNP)濃度的變化及其臨床意義.方法 選取健康體檢者15 例,穩定型心絞痛(SAP)患者15 例,ACS早期患者60 例[其中急性心肌梗死(AMI)組35例,不穩定型心絞痛(UA)組25 例].採用電化學髮光免疫法(ECLIA)測定血漿NT-proBNP濃度.結果 與健康對照組NT-proBNP比較,ACS患者血漿NT-proBNP濃度明顯升高(P<0.01),且AMI組NT-proBNP濃度[(1900.10±571.15)pg/mL]高于UA組[(312.78±44.47)pg/mL,P<0.01],SAP組與對照組比較差異無統計學意義.結論 血漿NT-proBNP濃度檢測可為ACS早期診斷提供非常有價值的參攷依據.
목적 탐토급성관맥종합정(ACS)환자조기안기말단-뇌납태전체(N-terminal pro-brain natriuretic peptide,NT-proBNP)농도적변화급기림상의의.방법 선취건강체검자15 례,은정형심교통(SAP)환자15 례,ACS조기환자60 례[기중급성심기경사(AMI)조35례,불은정형심교통(UA)조25 례].채용전화학발광면역법(ECLIA)측정혈장NT-proBNP농도.결과 여건강대조조NT-proBNP비교,ACS환자혈장NT-proBNP농도명현승고(P<0.01),차AMI조NT-proBNP농도[(1900.10±571.15)pg/mL]고우UA조[(312.78±44.47)pg/mL,P<0.01],SAP조여대조조비교차이무통계학의의.결론 혈장NT-proBNP농도검측가위ACS조기진단제공비상유개치적삼고의거.
Objective To explore the variation and clinical meaning of N-terminal pro brain natriuretic peptide in the patients with acute coronary syndrome(ACS)at the early stage(within 5 h).Methods Plasma NT-proBNP in 15 healthy volunteers,15 SAP patients and 60 ACS patients were tested by electro- chemiluminescence immunoassay(ECLIA).ACS patients were divided into unstable angina pectoris(UAP)group and acute myocardial infarction(AMI)group. Results Compared with healthy group(86.41±5.35)pg/mL and SAP group(99.62±5.43)pg/mL, the plasma NT-proBNP level in ACS group was significantly higher(P<0.01).The plasma NT-proBNP level in AMI group(1900.10±571.15)pg/mL was significantly higher than that (312.78±44.47)pg/mL in UAP group(P<0.01).But there was no significant difference in NT-proBNP level between SAP group and control group. Conclusion Plasma NT-proBNP levels increase significantly in the patients with ACS, and it seems more higher in the patients with AMI. Plasma NT-proBNP can be used as an early diagnostic parameter for acute coronary syndrome.
