CAJ | 학술논문

目的探讨特应性皮炎、慢性荨麻疹、慢性湿疹常见过敏原的可能致病情况.方法用标准变应原液在前臂屈侧皮肤进行皮肤点刺试验,分别用0.1%组胺和0.9%氯化钠液作阳性和阴性对照,统计分析采用x2检验.结果尘螨(屋尘螨+粉尘螨)的阳性率最高,达50.0%～78.6%,其次为动物毛,达7.1%～21.4%,霉菌的阳性率也较高,达7.1%～14.3%,并且这3种变应原在3种疾病间的阳性率差异均有统计学意义(P＜0.01),以特异性皮炎的阳性率最高.食物组过敏原中虾的阳性率(6.6%～14.3%)最高,但在3种疾病间的阳性率差异无统计学意义(P＞0.05);金枪鱼在慢性荨麻疹中的阳性率(9.5%)较高,鸡蛋、牛奶、芹菜在特异性皮炎中的阳性率(7.1%～14.3%)较高,这4种变应原在3种疾病间的阳性率差异均有统计学意义(P＜0.05).结论吸入组过敏原是慢性过敏性皮肤病的常见过敏原,尘螨为首要过敏原,以特异性皮炎的阳性率为最高.
목적 탐토특응성피염、만성담마진、만성습진상견과민원적가능치병정황.방법 용표준변응원액재전비굴측피부진행피부점자시험,분별용0.1%조알화0.9%록화납액작양성화음성대조,통계분석채용x2검험.결과 진만(옥진만+분진만)적양성솔최고,체50.0%～78.6%,기차위동물모,체7.1%～21.4%,매균적양성솔야교고,체7.1%～14.3%,병차저3충변응원재3충질병간적양성솔차이균유통계학의의(P＜0.01),이특이성피염적양성솔최고.식물조과민원중하적양성솔(6.6%～14.3%)최고,단재3충질병간적양성솔차이무통계학의의(P＞0.05);금창어재만성담마진중적양성솔(9.5%)교고,계단、우내、근채재특이성피염중적양성솔(7.1%～14.3%)교고,저4충변응원재3충질병간적양성솔차이균유통계학의의(P＜0.05).결론 흡입조과민원시만성과민성피부병적상견과민원,진만위수요과민원,이특이성피염적양성솔위최고.
Objective To assess the distribution of common allergens in atopic dermatitis, chronic urticaria and chronic eczema. Methods Skin prick tests were performed on the flexor surface of forearm of 816 patients with different chronic allergic dermatoses (including atopic dermatitis, chronic urticaria and chronic eczema) using standard allergen extracts, 0.1% histamine solution (positive control ) and physiological saline (negative control). Statistical analysis was carried out by the chi-square test. Results The sensitization rate to dust mite, which varied from 50.0% to 78.6%, was highest among the tested allergens, followed by that to animal hair (7.1%-21.4%) and mould (7.1%-14.3%). Also, statistically different sensitization rates to these three allergens were observed between patients with atopic dermatitis, chronic urticaria and chronic eczema (all P ＜ 0.01 ), and atopic dermatitis patients showed the highest sensitization rate to all the three allergens. No significant difference was observed in the sensitization rate to shrimp among the three groups of patients (P ＞ 0.05), although among food allergens, it was the most common sensitizing allergen with a sensitization rate of 6.6% to 14.3%. A relative increment was observed in the sensitization rate to tuna (9.5%)in patients with urticaria as well as in that to egg, milk and celery (7.1%-14.3%) in patients with atopic dermatitis; furthermore, a statistical difference was noted in the sensitization rate to the four allergens among the three groups of patients (all P ＜ 0.05). Conclusions Inhaled allergens are common sensitizing agents in chronic allergic skin diseases; dust mite predominates in these allergens, especially in patients with atopic dermatitis who exhibit the highest sensitization rate.