CAJ | 학술논문

目的观察MINE方案解救治疗复发或难治的中度恶性非霍奇金淋巴瘤(NHL)的近期疗效和不良反应.方法 45例经CHOP或CHOP类方案治疗失败的NHL患者接受2～6个周期的MINE方案化疗.异环磷酰胺(IFO)1.5 g/m2静脉滴注,第1天至第3天,配合美斯钠(Mesna)400 mg/次分别于IFO后0、4、8 h静脉滴注,第l天至第3天;米托蒽醌(MIT)10 mg/m2静脉滴注,第1天;依托泊苷(VP16)65mg/m2静脉滴注,第1天至第3天,以21～28 d为1个周期.疗效和不良反应按WHO标准判定.结果完全缓解(CR)9例.部分缓解(PR)15例.稳定(sD)13例,进展(PD)8例,总有效率(RR)53.3%.主要的不良反应为骨髓抑制、胃肠道反应和脱发.结论 MINE方案是复发或难治中度恶性NHL安全有效的解救治疗方案,值得进一步临床研究.
목적 관찰MINE방안해구치료복발혹난치적중도악성비곽기금림파류(NHL)적근기료효화불량반응.방법 45례경CHOP혹CHOP류방안치료실패적NHL환자접수2～6개주기적MINE방안화료.이배린선알(IFO)1.5 g/m2정맥적주,제1천지제3천,배합미사납(Mesna)400 mg/차분별우IFO후0、4、8 h정맥적주,제l천지제3천;미탁은곤(MIT)10 mg/m2정맥적주,제1천;의탁박감(VP16)65mg/m2정맥적주,제1천지제3천,이21～28 d위1개주기.료효화불량반응안WHO표준판정.결과 완전완해(CR)9례.부분완해(PR)15례.은정(sD)13례,진전(PD)8례,총유효솔(RR)53.3%.주요적불량반응위골수억제、위장도반응화탈발.결론 MINE방안시복발혹난치중도악성NHL안전유효적해구치료방안,치득진일보림상연구.
Objective To investigate the efficacy and side effects of MINE regimen, as a salvage regimen, in treating patients with recurrent and refractory intermediate grade non-Hodgkin lymphoma(NHL).Methods 45 patients failing to CHOP or CHOP-like regimen were treated with MINE regimen and every patient had received 2-6 cycles of treatment. IFO 15 g/m2, ivgtt on d1-3, combined with mesna 400 mg iv for3 times on Oh, 4h, 8h after IFO ivgtt; MIT 10 mg/m2 ivgtt on dl; VP1665 mg/m2 ivgtt on d1-3. 21-28 daysconsisted of one cycle. The therapeutic effects and side effects were evaluated according to the WHO criteria.Results In all 45 patients, 53.3 % of overall response rate were achieved CR for 9 cases, 15 cases PR, 13 cases SD and 8 cases PD. Main side effects were myelosuppression, nausea, vomit, alopecia, etc. Conclusion MINE regimen is an effective and safe salvage regimen in treating patients with recurrent and refractory intermediate grade NHL. Further clinical study on the application of MINE regimen is recommended.