CAJ | 학술논문

目的探讨乙型肝炎基因工程疫苗阻断 HBV母婴传播的免疫保护效果和免疫策略。方法对 HBsAg和 HBeAg 同时阳性母亲的 169例新生儿接种国产重组酵母乙型肝炎疫苗，于免后 3、 9、 12、 24、 36、 48月采血进行血清免疫学追踪观察。结果 22例婴儿 1岁前 HBsAg阳性， 19例（ 11.24％）成为慢性携带者，免后一年阻断保护率为 85.94％。抗 -HBs阳性率和抗 -HBs滴度均于 9～ 12月龄时达一高峰， 24和 36月龄时有所下降，免后 1～ 4年抗 -HBs阳性率分别为 96.43％、 91.07％、 85.19％和 70.00％。结论国产酵母重组乙型肝炎疫苗对 HBV母婴传播具有良好免疫阻断效果。母亲 HBsAg和 HBeAg双阳性的幼儿在 3～ 4岁时需加强免疫。
목적탐토을형간염기인공정역묘조단 HBV모영전파적면역보호효과화면역책략。방법대 HBsAg화 HBeAg 동시양성모친적 169례신생인접충국산중조효모을형간염역묘，우면후 3、 9、 12、 24、 36、 48월채혈진행혈청면역학추종관찰。결과 22례영인 1세전 HBsAg양성， 19례（ 11.24％）성위만성휴대자，면후일년조단보호솔위 85.94％。항 -HBs양성솔화항 -HBs적도균우 9～ 12월령시체일고봉， 24화 36월령시유소하강，면후 1～ 4년항 -HBs양성솔분별위 96.43％、 91.07％、 85.19％화 70.00％。결론국산효모중조을형간염역묘대 HBV모영전파구유량호면역조단효과。모친 HBsAg화 HBeAg쌍양성적유인재 3～ 4세시수가강면역。
Objective　To assess the efficacy and immunogenicity of recombinant yeast derived hepatitis B vaccine in infants born to HBsAg and HBeAg carrier mother.Methods　A total of 169 neonates born to HBsAg,HBeAg both positive mothers were vaccinated with 5,5,5 μ g doses of recombinant yeast derived hepatitis B vaccine by 0,1,6 months schedule.They were all followed for 3,9,12,24,36,48 months after the primary vaccination.Results　19 infants (11.24％) become HBsAg positively conversed in one year after primary vaccination,and the protective efficacy rate of interruption of perinatal transmission was 85.94％.The peak of conversion rate and titer of anti-HBs were observed in aged 9～12 months,and it decreased progressively at aged 24～36 months,the positive rates of anti-HBs were 96.43％,91.07％,85.19％ and 70.0％ ,respectively.Conclusion　The recombinant yeast derived hepatitis B vaccine has good immunogenicity and high protective efficacy in interruption of perinatal transmission,a booster dose seems necessary in aged 3-4 years after vaccination.