CAJ | 학술논문

目的研究鹿茸多胺的抗氧化作用.方法测定鹿茸多胺在体外对NADPH-维生素C和Fe 2+-半胱氨酸系统诱发的微粒体脂质过氧化反应(MDA形成)的影响,对黄嘌呤-黄嘌呤氧化酶系统超氧阴离子自由基(O-2)产生(还原型细胞色素C形成)的影响,在体内对CCl4和乙醇诱发的小鼠肝脂质过氧化反应(MDA形成)的影响.结果鹿茸多胺在体外能明显抑制NADPH-维生素C和Fe2+-半胱氨酸系统诱发的大鼠脑、肝、肾微粒体脂质过氧化反应(MDA形成),及黄嘌呤-黄嘌呤氧化酶系统O-2的产生(还原型细胞色素C形成).在体内能抑制CCl4和乙醇诱发的小鼠肝脂质过氧化反应(MDA形成).结论鹿茸多胺具有抗氧化作用.
목적연구록용다알적항양화작용.방법측정록용다알재체외대NADPH-유생소C화Fe 2+-반광안산계통유발적미립체지질과양화반응(MDA형성)적영향,대황표령-황표령양화매계통초양음리자자유기(O-2)산생(환원형세포색소C형성)적영향,재체내대CCl4화을순유발적소서간지질과양화반응(MDA형성)적영향.결과록용다알재체외능명현억제NADPH-유생소C화Fe2+-반광안산계통유발적대서뇌、간、신미립체지질과양화반응(MDA형성),급황표령-황표령양화매계통O-2적산생(환원형세포색소C형성).재체내능억제CCl4화을순유발적소서간지질과양화반응(MDA형성).결론록용다알구유항양화작용.
Object To investigate the antioxidant activity of polyamines isolated from pilose antler(paipa).Mthods The effects of PAIPA ON the lipid peroxidation(MDA formation)in microsomes of rat brain,liver ,and kidney induced by NADPH-Vitamine C(Vc)and ferrous-cysteine systems in vitro,the superoxide anion radical production(reduced cytochrome C formation)inxanthine-xanthine oxidase system in vitro,and the CCL4-and ethanol-induced MDA formation in mice liver in vivo were evaluated.Results PAIPA could significantly inhibit the lipid peroxidation(MDA formation)in microsomes of rat brain,liver,and kidney induced by NADPH-Vc and ferrous -cyctein,the superoxide anion radical produc-tion(formation of reduced cytochrome C)in xanthine-oxidase system in vitro,and the CCL4-and ethanol-induced MDA formation in mice liver in vivo.Conclusion PAIPA exhibits an antioxidant activity.