北京医学
北京醫學
북경의학
BEIJING MEDICAL JOURNAL
2010年
3期
176-179
,共4页
徐艳利%陈志海%肖江%廖华%闫杰%胡居龙%贾哲%李晓光%于芸%李兴旺
徐豔利%陳誌海%肖江%廖華%閆傑%鬍居龍%賈哲%李曉光%于蕓%李興旺
서염리%진지해%초강%료화%염걸%호거룡%가철%리효광%우예%리흥왕
甲型H1N1流感%奥司他韦%自然病程
甲型H1N1流感%奧司他韋%自然病程
갑형H1N1류감%오사타위%자연병정
Influenza A(H1N1)%Oseltamivir%Natural history
目的 研究甲型H1N1流感患者在非干预自然状态下的病情演变过程及预后,并与应用奥司他韦(达菲)治疗患者进行对照研究. 方法 对93例甲型H1N1流感确诊患者进行前瞻性临床观察,将入院时发病时间>48h的51例患者纳入不应用奥司他韦治疗的非干预组,将发病时间≤48h者的42例患者纳入奥司他韦组,比较两组患者的临床特征、症状持续时间、病毒转阴时间以及奥司他韦对患者病程的影响. 结果 两组患者临床表现较季节性流感轻,生化检查基本正常.非干预组发热持续时间为(4.16±3.04)d,病毒核酸转阴时间为(5.79±1.91)d;奥司他韦组发热持续时间为(2.53±1.46)d,病毒核酸转阴时间为(4.91±1.44)d;两组比较有显著性差异. 结论 甲型H1N1流感患者病情表现较为温和,流感样症状轻,轻症患者可呈自限性经过,可不予奥司他韦治疗,但隔离时间应适当延长至病后7d.
目的 研究甲型H1N1流感患者在非榦預自然狀態下的病情縯變過程及預後,併與應用奧司他韋(達菲)治療患者進行對照研究. 方法 對93例甲型H1N1流感確診患者進行前瞻性臨床觀察,將入院時髮病時間>48h的51例患者納入不應用奧司他韋治療的非榦預組,將髮病時間≤48h者的42例患者納入奧司他韋組,比較兩組患者的臨床特徵、癥狀持續時間、病毒轉陰時間以及奧司他韋對患者病程的影響. 結果 兩組患者臨床錶現較季節性流感輕,生化檢查基本正常.非榦預組髮熱持續時間為(4.16±3.04)d,病毒覈痠轉陰時間為(5.79±1.91)d;奧司他韋組髮熱持續時間為(2.53±1.46)d,病毒覈痠轉陰時間為(4.91±1.44)d;兩組比較有顯著性差異. 結論 甲型H1N1流感患者病情錶現較為溫和,流感樣癥狀輕,輕癥患者可呈自限性經過,可不予奧司他韋治療,但隔離時間應適噹延長至病後7d.
목적 연구갑형H1N1류감환자재비간예자연상태하적병정연변과정급예후,병여응용오사타위(체비)치료환자진행대조연구. 방법 대93례갑형H1N1류감학진환자진행전첨성림상관찰,장입원시발병시간>48h적51례환자납입불응용오사타위치료적비간예조,장발병시간≤48h자적42례환자납입오사타위조,비교량조환자적림상특정、증상지속시간、병독전음시간이급오사타위대환자병정적영향. 결과 량조환자림상표현교계절성류감경,생화검사기본정상.비간예조발열지속시간위(4.16±3.04)d,병독핵산전음시간위(5.79±1.91)d;오사타위조발열지속시간위(2.53±1.46)d,병독핵산전음시간위(4.91±1.44)d;량조비교유현저성차이. 결론 갑형H1N1류감환자병정표현교위온화,류감양증상경,경증환자가정자한성경과,가불여오사타위치료,단격리시간응괄당연장지병후7d.
Object To study the natural history of influenza A(H1N1)viral infection,and compare between natural history and Oseltamivir treating in group A (H1N1)viral infection Methods The prospective study was adopted to observe the clinical features of 93 patients with pandemic influenza A(H1N1)virus infection who were hospitalized in Beijing Ditan Hospital.Ninty-three patients were divided into two groups,51 patients trentment that was more than 48 hours after onset of illness were received the non-antiviral,42 patients that was within 48 hours after onset of illness were received Oseltamivir therapy.The clinical feature,the course of illness,prognosis,the time of symptom disappearing and RNA shedding,and the effect of Oseltamivir contributing the course of the illness were abserved. Results The symptoms of both groups patients were mild,and the examination results were general normal.However,the time of fever persistance in the non-antiviral group and antiviral group was(4.16±3.04)days and(2.53±1.46)days,According to rRT-PCR results,the time of RNA shedding in the non-antiviral group and antiviral group was(5.79±1.91)days and(4.91±1.44)days.There were significant differences between the two groups as to fever persistance and RNA shedding time(P<0.05). Conclusions The symptoms of the patients with the pandemic 2009 influenza A H1N1 virus infection were relatively mild,the course of disease in the mild patients presented natural limited,which may not be given Oseltamivir therapy.Nevertheless,the separated period needs to prolong to 7 days from onset of illness.
