CAJ | 학술논문

抑癌基因启动子过甲基化是除基因突变和染色体物质缺失外抑癌基因失活的第3种机制,某些情况下是抑癌基因失活的惟一机制.目前抑癌基因启动子过甲基化已被用于肺癌的诊断、筛查和监测肿瘤复发的研究.本文对抑癌基因启动子过甲基化导致肺癌发生的基础、研究过甲基化的方法、过甲基化研究在临床的应用、逆转过甲基化的探讨及目前研究的局限性作一综述.
억암기인계동자과갑기화시제기인돌변화염색체물질결실외억암기인실활적제3충궤제,모사정황하시억암기인실활적유일궤제.목전억암기인계동자과갑기화이피용우폐암적진단、사사화감측종류복발적연구.본문대억암기인계동자과갑기화도치폐암발생적기출、연구과갑기화적방법、과갑기화연구재림상적응용、역전과갑기화적탐토급목전연구적국한성작일종술.
Except gene mutation and loss of heterozygosity,anti-oncogene promoter hypermethylation is another mechanism leading to anti-oncogene inactive,and it is the only mechanism in some condition. Now anti-oncogene promoter hypermethylation is used in the field of diagnosis, screening and monitoring relapse of lung cancer. This review summarizes mechanisms of anti-oncogene promoter hypermethylation leading to lung cancer, methods of hypermethylation, clinical application of hypermethylation, epigenetic therapies of hypermethylation and limit of current hypermethylation research.