CAJ | 학술논문

目的探讨EphA2和E-eadherin在大肠癌组织中的表达及其临床意义.方法采用免疫组织化学S-P方法检测67例大肠癌和28例正常大肠黏膜组织中EphA2和E-cadherin的表达,并分析其与临床病理因素的关系.结果大肠癌组织中EphA2阳性和E-cadherin阴性表达均显著高于正常大肠黏膜组织(P<0.01).EphA2阳性和E-cadherin阴性表达与大肠癌分化程度、浸润深度和淋巴结转移差异有统计学意义(P<0.01或P<0.05),而与大肠癌大体类型差异无统计学意义(P>0.05).EphA2与E-cadherin表达呈负相关(r=-0.45,P<0.05).结论 EphA2与E-cedherin异常表达可能共同参与大肠癌的发生、发展与转移,EphA2可与E-eadherin结合作为判断大肠癌恶性程度和预后的指标.
목적 탐토EphA2화E-eadherin재대장암조직중적표체급기림상의의.방법 채용면역조직화학S-P방법검측67례대장암화28례정상대장점막조직중EphA2화E-cadherin적표체,병분석기여림상병리인소적관계.결과 대장암조직중EphA2양성화E-cadherin음성표체균현저고우정상대장점막조직(P<0.01).EphA2양성화E-cadherin음성표체여대장암분화정도、침윤심도화림파결전이차이유통계학의의(P<0.01혹P<0.05),이여대장암대체류형차이무통계학의의(P>0.05).EphA2여E-cadherin표체정부상관(r=-0.45,P<0.05).결론 EphA2여E-cedherin이상표체가능공동삼여대장암적발생、발전여전이,EphA2가여E-eadherin결합작위판단대장암악성정도화예후적지표.
Objective To explore the expression and clinical significance of EphA2 and E-eadherin in colorectal carcinoma.Methods The expression of EphA2 and E-eadherin in 67 cases of eoloreetal carcinoma and 28 cases of normal large intestine tissues were determined by immunohistochemieal method(S-P method),and their relationship to elinicopathological characteristics were analyzed.Results The positive expression of EphA2 and negative expression of E-cadherin in colorectul carcinoma tissues were significantly higher than those in normal intestine tissues(P<0.01).F111e positive expression of EphA2 and negative expression of E-eadherin were positively correlated with tumor histological grade,invasive depth and lymph node metastasis(P<0.01 orP<0.05),but not correlated with tumor～ross type(P> O.05).The expression of EphA2 was negatively related with E-cadherin.Conclusions The abnormal expression of EphA2 and E-cadherin may be together involved in the development and progression of eolorectal carcinoma,It may be a good marker for monitoring the malignant degree and the prognosis of colorectal carcinoma by combining E-eadherin and EphA2.