中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2011年
2期
167-169
,共3页
任淑敏%吕少妮%刘传新%韩秀涛%朱启贞%田永晓
任淑敏%呂少妮%劉傳新%韓秀濤%硃啟貞%田永曉
임숙민%려소니%류전신%한수도%주계정%전영효
抑郁症%5-羟色胺转运体%5-HTTLPR%遗传学%基因%Meta分析
抑鬱癥%5-羥色胺轉運體%5-HTTLPR%遺傳學%基因%Meta分析
억욱증%5-간색알전운체%5-HTTLPR%유전학%기인%Meta분석
Depression%5-HTT%5-HTTLPR%Genetics%Genes%Meta analysis
目的 综合评价5-羟色胺转运体基因多态性与抑郁症的关系.方法 检索CBMdisc和PubMed数据库(2000～2009年),依据选择标准收集所有相关病例对照研究,应用RevMan 4.2.2软件对符合条件的研究结果进行meta分析.结果 共纳入14篇符合条件的文献,累计病例1284例、对照1243例.数据合并结果显示,SS基因型使抑郁症的发病风险高出46%[合并OR值及95%可信区间为1.64(1.37～1.97)],P＜0.00001;SL基因型合并OR值(95%CI)为0.82(0.66～1.03),P＞0.01;LL基因型合并OR值(95%CI)为0.74(0.61～0.90),P＜0.01.结论 5-羟色胺转运体基因多态性与抑郁症有关,其中SS基因型是抑郁症的易感基因,LL基因型可能是抑郁症的保护因子.
目的 綜閤評價5-羥色胺轉運體基因多態性與抑鬱癥的關繫.方法 檢索CBMdisc和PubMed數據庫(2000～2009年),依據選擇標準收集所有相關病例對照研究,應用RevMan 4.2.2軟件對符閤條件的研究結果進行meta分析.結果 共納入14篇符閤條件的文獻,纍計病例1284例、對照1243例.數據閤併結果顯示,SS基因型使抑鬱癥的髮病風險高齣46%[閤併OR值及95%可信區間為1.64(1.37～1.97)],P＜0.00001;SL基因型閤併OR值(95%CI)為0.82(0.66～1.03),P＞0.01;LL基因型閤併OR值(95%CI)為0.74(0.61～0.90),P＜0.01.結論 5-羥色胺轉運體基因多態性與抑鬱癥有關,其中SS基因型是抑鬱癥的易感基因,LL基因型可能是抑鬱癥的保護因子.
목적 종합평개5-간색알전운체기인다태성여억욱증적관계.방법 검색CBMdisc화PubMed수거고(2000～2009년),의거선택표준수집소유상관병례대조연구,응용RevMan 4.2.2연건대부합조건적연구결과진행meta분석.결과 공납입14편부합조건적문헌,루계병례1284례、대조1243례.수거합병결과현시,SS기인형사억욱증적발병풍험고출46%[합병OR치급95%가신구간위1.64(1.37～1.97)],P＜0.00001;SL기인형합병OR치(95%CI)위0.82(0.66～1.03),P＞0.01;LL기인형합병OR치(95%CI)위0.74(0.61～0.90),P＜0.01.결론 5-간색알전운체기인다태성여억욱증유관,기중SS기인형시억욱증적역감기인,LL기인형가능시억욱증적보호인자.
Objective To assess the associations of 5-HTT gene polymorphism with depression by Metaanalysis.Method A comprehensive search for articles from January 2000 to July 2009 was conducted from Chinese BioMedical Literature Database on disc (CBMdisc) and PubMed databases.All related case-control studies were collected and the results were analyzed using RevMan 4.2.2 software.Results A total of 1284 cases and 1243 controls were collected from 14 studies.The combined data statistics revealed that the pooled ORs ( 95%CI) for genotype SS,SL,LL were 1.64 ( 1.37 ～1.97) (P＜0.00001),0.82 (0.66 ～ 1.03) (P＞0.01) and 0.74 (0.61 ～ 0.90) (P ＜ 0.01 ) respectively.Conclusions Polymorphisms of 5-HTT gene have significant association with depression,SS genotype may increase the risk for depression,LL genotype may be protective factors for depression.
