CAJ | 학술논문

放射性肺纤维化是胸部肿瘤放疗及骨髓移植预处理中常见而难治的并发症.近年来对放射性肺纤维化形成机制的最重要的认识就是细胞因子作为中心环节启动和维持胶原蛋白代谢调控失衡,使得放射性肺纤维化成为一个正反馈的进行性加重过程.细胞因子的合成受到转录因子调控,其调控过程错综复杂.钙振荡作为普遍存在的信号形式能够高效、特异地调节转录因子的活性和细胞因子表达·与放射性肺纤维化的形成机制相关联.
방사성폐섬유화시흉부종류방료급골수이식예처리중상견이난치적병발증.근년래대방사성폐섬유화형성궤제적최중요적인식취시세포인자작위중심배절계동화유지효원단백대사조공실형,사득방사성폐섬유화성위일개정반궤적진행성가중과정.세포인자적합성수도전록인자조공,기조공과정착종복잡.개진탕작위보편존재적신호형식능구고효、특이지조절전록인자적활성화세포인자표체·여방사성폐섬유화적형성궤제상관련.
Radiation pulmonary fibrosis is a common and incurable complication in thoracic radiotherapy for breast neoplasm and total body irradiation for pretreatment before bone marrow transplantation. In recent years, the most important knowledge about radiation pulmonary fibrosis is that the cytokines play the most important role in starting and maintaining collagen metabolic unbalance. And cytokines cause the formation of radiation pulmonary fibrosis as a regenerative and aggravating process. Expression of cytokines is controlled by transcription factors, and the adjustment process is intricate. Calcium oscillation,a common form of signal, can effectively adjust the transcription factor activity and cytokine expression. It is related to the mechanism of radiation pulmonary fibrosis.