CAJ | 학술논문

目的探讨母亲怀孕前后被动吸烟与子代发生神经管畸形(NTD)危险性的关系.方法资料来源于北京大学生育健康研究所在山西省平定、昔阳、太谷和泽州4个县开展的以人群为基础的出生缺陷病例对照研究.病例为2003年1月到2007年6月监测到的515例NTD病例(其中无脑儿236例,脊柱裂237例,脑膨出42例),对照组为同期在同地区调查的682例无体表出生缺陷的婴儿.研究人员在妇女分娩一周内问卷调查妇女怀孕前后的被动吸烟及其他信息.用非条件logistic回归模型调整混杂因素.结果与无被动吸烟的妇女相比,怀孕前后有被动吸烟的妇女生育NTD的危险性(OR值)为1.84(95%CI:1.39～2.44).妇女被动吸烟频度与子代发生NTD危险性之间存在显著的剂量反应关系.与无被动吸烟的妇女相比,偶尔有被动吸烟的妇女和每天有被动吸烟的妇女生育NTD的OR值分别为1.51和2.44(趋势x2=24.9,P＜0.001).结论妇女怀孕前后被动吸烟增加生育NTD患儿的危险性.
목적 탐토모친부잉전후피동흡연여자대발생신경관기형(NTD)위험성적관계.방법 자료래원우북경대학생육건강연구소재산서성평정、석양、태곡화택주4개현개전적이인군위기출적출생결함병례대조연구.병례위2003년1월도2007년6월감측도적515례NTD병례(기중무뇌인236례,척주렬237례,뇌팽출42례),대조조위동기재동지구조사적682례무체표출생결함적영인.연구인원재부녀분면일주내문권조사부녀부잉전후적피동흡연급기타신식.용비조건logistic회귀모형조정혼잡인소.결과 여무피동흡연적부녀상비,부잉전후유피동흡연적부녀생육NTD적위험성(OR치)위1.84(95%CI:1.39～2.44).부녀피동흡연빈도여자대발생NTD위험성지간존재현저적제량반응관계.여무피동흡연적부녀상비,우이유피동흡연적부녀화매천유피동흡연적부녀생육NTD적OR치분별위1.51화2.44(추세x2=24.9,P＜0.001).결론 부녀부잉전후피동흡연증가생육NTD환인적위험성.
Objective To explore the relationship between maternal passive smoking during early pregnancy and the risk of neural tube defects (NTDs). Methods Data was derived from a populationbased case-control study on birth defects in Shanxi province. The study subjects included 515 NTDs defects cases (236 cases of anencephaly, 237 spina bifida and 42 encephalocele) ascertained during January 2003 and June 2007 in the study areas and 682 normal controls randomly selected in the same residence during the same period as cases. Results The risk of NTDs in their offspring was 1.84 (95 % CI : 1.39-2.44) for mothers with passive smoking history during peri-conceptional period. There was a marked dose-response relation between maternal passive smoking and the risk of NTDs in offspring. Compared to the women without passive smoking, the NTDs risk in offspring was 1.51 for women with occasional passive smoking and 2.44 for women with passive smoking for almost everyday during the peri-conceptional period.Conclusion Maternal passive smoking during peri-conceptional period increased the risk of NTDs in offspring.