CAJ | 학술논문

目的探讨TK1在乳腺癌发生、发展中的意义及与Ki67表达的相关性.方法应用免疫组织化学SABC法和S-P法检测TK1和Ki67在89例乳腺癌组织中的表达.结果 TK1在乳腺癌组织中阳性表达率为69.7%(62/89),且与淋巴结转移、TNM分期、组织学分级密切相关(P<0.05),与患者年龄无关(P>0.05).乳腺癌组织中TK1表达与Ki67表达没有显著的相关性(P>0.05).结论 TK1表达与乳腺癌的发生、发展密切相关,其高表达是乳腺癌预后不良的指标.TKI和Ki67是独立的乳腺癌细胞增殖指标.
목적 탐토TK1재유선암발생、발전중적의의급여Ki67표체적상관성.방법 응용면역조직화학SABC법화S-P법검측TK1화Ki67재89례유선암조직중적표체.결과 TK1재유선암조직중양성표체솔위69.7%(62/89),차여림파결전이、TNM분기、조직학분급밀절상관(P<0.05),여환자년령무관(P>0.05).유선암조직중TK1표체여Ki67표체몰유현저적상관성(P>0.05).결론 TK1표체여유선암적발생、발전밀절상관,기고표체시유선암예후불량적지표.TKI화Ki67시독립적유선암세포증식지표.
Objective To explore the expression of TK1 in breast carcinoma and discuss its significance of carcinogenesis and progression in breast carcinoma and its relationship with Ki67. Method Using immunohistochemistry methods of SABC and S-P to detect the expression of TK1 and Ki67 in 89 cases of breast carcinoma tissue. Results Positive rate of TK1 in the breast carcinoma was 69.7% (62/89), and the expression of TK1 was significantly associated with lymph node metastasis, TNM stage and histological grade (P < 0.05), but it was not significantly correlated with age (P > 0.05). The expression of TK1 was not significantly correlated with Ki67 in the breast carcinoma (P>0.05). Conclusions Expression of TK1 is associated with carcinogenesis and progression, and it is a poor prognostic marker of breast carcinoma. TK1 and Ki67 are the indicators of cellular growth independently.