CAJ | 학술논문

目的探讨不同复苏液体种类对大鼠急性失血性休克微循环的影响.方法对40只纯种Wistar大鼠参照Sandro B.Rizoli所建模型改良复制失血性休克动物模型,根据对急性失血性休克大鼠进行液体复苏时所选液体种类不同,随机分为无液体复苏组(A组)、低分子右旋糖苷-40组(B组)、7.5%高渗盐水组(C组)和高渗盐水+低分子右旋糖苷-40(D组),每组10只,于休克后24 h将动物处死,采集左侧肾皮质相应部位标本用于电镜检查.结果休克无液体复苏组(A组)动物肾脏微循环破坏严重,单独应用低分子右旋糖苷组(B组)或单独应用高渗盐水组(C组)均有不同程度损伤,而联合应用高渗盐水+低右复苏组(D组)肾脏微循环基本完好.结论不同复苏液体种类对休克机体微循环影响不同,联合应用高渗盐水+低右对保护肾脏微循环具有良好效果.
목적 탐토불동복소액체충류대대서급성실혈성휴극미순배적영향.방법 대40지순충Wistar대서삼조Sandro B.Rizoli소건모형개량복제실혈성휴극동물모형,근거대급성실혈성휴극대서진행액체복소시소선액체충류불동,수궤분위무액체복소조(A조)、저분자우선당감-40조(B조)、7.5%고삼염수조(C조)화고삼염수+저분자우선당감-40(D조),매조10지,우휴극후24 h장동물처사,채집좌측신피질상응부위표본용우전경검사.결과 휴극무액체복소조(A조)동물신장미순배파배엄중,단독응용저분자우선당감조(B조)혹단독응용고삼염수조(C조)균유불동정도손상,이연합응용고삼염수+저우복소조(D조)신장미순배기본완호.결론 불동복소액체충류대휴극궤체미순배영향불동,연합응용고삼염수+저우대보호신장미순배구유량호효과.
Objective To investigate the effects of different means of liquid resuscitation on microcirculation in rats with hemorrhagic shock. Method A model of rats with hemorrhagic shock was established in 40 Wistar rats. The rats were randomly divided into 4 groups according on different means of liquid resuscitation, and killed 24 hours after the examination, group A: without liquid resuscitation; group B: low-molecular-weight-40; group C: 7.5% hypertonic saline,group D:low-molecular-weight-40 + hyperonic saline. As well as the microcirculation in kidney was observed using electron microscope. Results In group without resuscitation, the microcirculation in kidney damaged severely; While in group with hypertonic or low molecule dextran alone, there was harm with dif-ferent degrees, and the microcirculation in kidney was nearly perfect in group with both hypertonic and low molecule dextran alone. Conclusions Different means of liquid resuscitation may infect the microcirculation in kidney, which with both hypertonic and low molecule dextran can protect the microcirculation in kidney.