CAJ | 학술논문

Perilipin是一种脂滴相关蛋白,包被于脂肪细胞和甾体生成细胞的脂滴表面.因其独特的组织分布和分子结构,Perilipin具有双向调控脂肪分解的功能.目前许多研究表明,Perilipin在肥胖和胰岛素抵抗中占有重要作用.Perilipin基因的缺失和基因多态性与肥胖、胰岛素抵抗的发生、发展及易感性密切相关.其可能成为治疗这些相关疾病的新靶点.
Perilipin시일충지적상관단백,포피우지방세포화치체생성세포적지적표면.인기독특적조직분포화분자결구,Perilipin구유쌍향조공지방분해적공능.목전허다연구표명,Perilipin재비반화이도소저항중점유중요작용.Perilipin기인적결실화기인다태성여비반、이도소저항적발생、발전급역감성밀절상관.기가능성위치료저사상관질병적신파점.
Perilipin is a lipid droplets-associated protein associating with the lipid droplets in adipocytes and steroidogenic cells.Because of its unique tissue distribution and molecular structure,Perilipin has a dual role in lipolysis regulation.Many studies have explored the significant association of Perilipin with obesity and insulin resistance.Furthermore,Perilipin ablation and its single nucleotide polymorphisms are significantly related to the development and susceptibility of obesity,insulin resistance.Perilipin may be a new useful target in treatment of these diseases.