CAJ | 학술논문

长期使用阿片类物质如吗啡的主要限制在于生理耐受性的发生.耐受使吗啡的镇痛效果明显减弱.现从阿片受体下调、失敏感、G-蛋白下游信号转导等方面,将阿片受体参与吗啡镇痛耐受机制的研究进展作一综述.
장기사용아편류물질여마배적주요한제재우생리내수성적발생.내수사마배적진통효과명현감약.현종아편수체하조、실민감、G-단백하유신호전도등방면,장아편수체삼여마배진통내수궤제적연구진전작일종술.
The major limitation to a long-term use of opioids, such as morphine, is the development of physiological tolerance,ob-served as a profound decrease in analgesic effect. Although the molecular and cellular mechanisms underlying the development of mor-phine tolerance remain controversial, great progress has been made. This review focuses on the opioid receptor with the aim of gaining a greater insight into the mechanism of morphine tolerance to analgesia.