中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2012年
22期
1553-1555
,共3页
血管黏液瘤%临床病理%免疫组化
血管黏液瘤%臨床病理%免疫組化
혈관점액류%림상병리%면역조화
Angiomyxoma%Clinicopathology%Immunohistochemistry
目的 探讨侵袭性血管黏液瘤的临床特点与病理特征,以提高诊治水平.方法 对7例侵袭性血管黏液瘤进行组织形态学和免疫组化分析,免疫组化采用Vimentin、Desmin、CD34、SMA、ER、PR、AR、S-100、p53、Ki67等抗体进行染色观察.结果 7例患者中男3例,女4例；年龄在29 ～72岁之间,平均43.1岁,女性平均年龄低于男性.排尿困难3例,其他无症状.所有患者均经手术切除,其中3例术后复发.大体肿瘤结节状,无包膜,切面黏液胶冻状,镜检示在黏液样背景中梭形、星形细胞散在分布,细胞无异型,伴见大小不一薄壁或厚壁血管,血管旁可见平滑肌样细胞束,肿瘤周边向正常组织浸润生长.疫组化染色显示肿瘤细胞表达Vimentin(+)7/7、Desmin(+)7/7、CD34(+)3/7、SMA(+ )2/7、ER(+ )6/7、p53(+ )4/7、Ki67( +)1％ ～8％而PR、AR、S-100阴性.结论 侵袭性血管黏液瘤罕见,而发生在男性的更为罕见,由于它具有侵袭性和高复发性,治疗以扩大切除为宜,并需长期随访.
目的 探討侵襲性血管黏液瘤的臨床特點與病理特徵,以提高診治水平.方法 對7例侵襲性血管黏液瘤進行組織形態學和免疫組化分析,免疫組化採用Vimentin、Desmin、CD34、SMA、ER、PR、AR、S-100、p53、Ki67等抗體進行染色觀察.結果 7例患者中男3例,女4例；年齡在29 ～72歲之間,平均43.1歲,女性平均年齡低于男性.排尿睏難3例,其他無癥狀.所有患者均經手術切除,其中3例術後複髮.大體腫瘤結節狀,無包膜,切麵黏液膠凍狀,鏡檢示在黏液樣揹景中梭形、星形細胞散在分佈,細胞無異型,伴見大小不一薄壁或厚壁血管,血管徬可見平滑肌樣細胞束,腫瘤週邊嚮正常組織浸潤生長.疫組化染色顯示腫瘤細胞錶達Vimentin(+)7/7、Desmin(+)7/7、CD34(+)3/7、SMA(+ )2/7、ER(+ )6/7、p53(+ )4/7、Ki67( +)1％ ～8％而PR、AR、S-100陰性.結論 侵襲性血管黏液瘤罕見,而髮生在男性的更為罕見,由于它具有侵襲性和高複髮性,治療以擴大切除為宜,併需長期隨訪.
목적 탐토침습성혈관점액류적림상특점여병리특정,이제고진치수평.방법 대7례침습성혈관점액류진행조직형태학화면역조화분석,면역조화채용Vimentin、Desmin、CD34、SMA、ER、PR、AR、S-100、p53、Ki67등항체진행염색관찰.결과 7례환자중남3례,녀4례；년령재29 ～72세지간,평균43.1세,녀성평균년령저우남성.배뇨곤난3례,기타무증상.소유환자균경수술절제,기중3례술후복발.대체종류결절상,무포막,절면점액효동상,경검시재점액양배경중사형、성형세포산재분포,세포무이형,반견대소불일박벽혹후벽혈관,혈관방가견평활기양세포속,종류주변향정상조직침윤생장.역조화염색현시종류세포표체Vimentin(+)7/7、Desmin(+)7/7、CD34(+)3/7、SMA(+ )2/7、ER(+ )6/7、p53(+ )4/7、Ki67( +)1％ ～8％이PR、AR、S-100음성.결론 침습성혈관점액류한견,이발생재남성적경위한견,유우타구유침습성화고복발성,치료이확대절제위의,병수장기수방.
Objective To explore the clinicopathological characteristics of aggressive angiomyxoma (AAM) so as to boost the level of diagnosis and treatment.Methods Seven cases of aggressive angiomyxoma were studied with light microscope and immunohistochemistry.Antibody of Vimentin,Desmin,CD34,smooth muscle actin ( SMA ),estrogen receptor (ER),progesterone receptor ( PR ),androgen receptor (AR),S-100,p53 and Ki67 were used.Results There were 3 males and 4 females with an average age of 43.1 years.Three patients had urinary compressive complaints while others were symptomfree.All underwent surgical resection. Three patients were recurrent after operation. The tumor was generally nodular and its cut surface appeared jelly-like.Histologically,on myxoid stroma background,it was composed of a mixture of spindle and stellar cells without atypical cell and mitosis.There were varioussized vessels with thin to thick walls.The scattered muscle-like cells had a perivascular distribution.Immunohistochemistry showed tha(t) tumor cells were positive for Vimentin( + )7/7,Desmin( + )7/7,CD34 ( + )3/7,SMA( + )2/7,ER( + )6/7,p53( + )4/7,Ki67( + ) 1％ -8％ and negative for PR,AR and S-100.Conclusions As a rare soft tissue tumor,AAM extremely rare in males.Owing to its local invasion and high recurrence,extensive resection and long-term follow-up are necessary.
