CAJ | 학술논문

目的:观测纳米银敷料结合重组牛碱性成纤维细胞生长因子凝胶治疗烧伤残余创面的疗效.方法:选取临床深II度及III度烧伤所致残余创面患者40例,随机分为两组,每组20例.治疗组应用纳米银敷料结合重组牛碱性成纤维细胞生长因子凝胶进行换药:对照组应用生理盐水和无菌石蜡油纱布换药.观测记录各组病例的愈合时间、创面感染例数、不同时相点创面愈合率、各组治疗前和治疗7 d时创面细菌培养情况、药物不良反应.结果:治疗组的愈合时间明显短于对照组(P<0.01);治疗组不同时相点创面愈合率明显高于对照组(P<0.01);治疗组创面感染例数明显少于对照组(P<0.01);治疗7 d后,治疗组致病细菌检出率明显低于对照组(P<0.01).结论:将纳米银敷料结合重组牛碱性成纤维细胞生长因子凝胶应用于可以非手术治疗的烧伤残余创面,有较好的抗菌作用及促进创面修复作用,能有效缩短烧伤残余创面的愈合时间.
목적:관측납미은부료결합중조우감성성섬유세포생장인자응효치료소상잔여창면적료효.방법:선취림상심II도급III도소상소치잔여창면환자40례,수궤분위량조,매조20례.치료조응용납미은부료결합중조우감성성섬유세포생장인자응효진행환약:대조조응용생리염수화무균석사유사포환약.관측기록각조병례적유합시간、창면감염례수、불동시상점창면유합솔、각조치료전화치료7 d시창면세균배양정황、약물불량반응.결과:치료조적유합시간명현단우대조조(P<0.01);치료조불동시상점창면유합솔명현고우대조조(P<0.01);치료조창면감염례수명현소우대조조(P<0.01);치료7 d후,치료조치병세균검출솔명현저우대조조(P<0.01).결론:장납미은부료결합중조우감성성섬유세포생장인자응효응용우가이비수술치료적소상잔여창면,유교호적항균작용급촉진창면수복작용,능유효축단소상잔여창면적유합시간.
OBJECTIVE: To investigate the curative effects of nanometer silver dressing and recombinant bovine basic fibroblast growth factor gel on burn residual wounds.METHODS: Forty burn patients with residual wounds because of deep second degree burn and full-thickness burn, were randomly divided into control group and management group. There were 20 patients in both groups. The patients of management group were treated by nanometer silver dressing and recombinant bovine basic fibroblast growth factor gel. The patients of control group were treated by saline and paraffin absorbent gauze. Healing time, wound healing rates at different time points,cases of infected wound and results of bacterial culture before and 7 days following treatment, and drug adverse reaction were recorded.RESULTS: The healing time of management group was significantly shorter than the control group (P < 0.01). The wound healing rates of management group was significantly higher than the control group at different time points (P< 0.01). The cases of infected wound was significantly fewer than the control group after treating (P < 0.01). The pathogenic bacteria detection rate was significantly lower than the control group after 7 days (P < 0.01).CONCLUSION: There was better antibacterial activity, decurtating the healing time when the management of nanometer silver dressing and recombinant bovine basic fibroblast growth factor gel on burn residual wounds were put into practice.