有机化学
有機化學
유궤화학
CHINESE JOURNAL OF ORGANIC CHEMISTRY
2009年
12期
1869-1889
,共21页
孙海口%林英杰%吴毓林%伍贻康
孫海口%林英傑%吳毓林%伍貽康
손해구%림영걸%오육림%오이강
流感(流行性感冒)%抗流感药%达菲%合成
流感(流行性感冒)%抗流感藥%達菲%閤成
류감(류행성감모)%항류감약%체비%합성
influenza%anti-influenza drug%tamiflu%synthesis
流行性感冒是由流感病毒引起的呼吸道疾病,传染性很强、对人类健康构成实质性的威胁.由于流感病毒多变,临床上用于治疗流感的药物到目前为止仅有"达菲"等有限的几种.本文将文献中已有报道的"达菲"的合成路线汇总并进行简要的综述.
流行性感冒是由流感病毒引起的呼吸道疾病,傳染性很彊、對人類健康構成實質性的威脅.由于流感病毒多變,臨床上用于治療流感的藥物到目前為止僅有"達菲"等有限的幾種.本文將文獻中已有報道的"達菲"的閤成路線彙總併進行簡要的綜述.
류행성감모시유류감병독인기적호흡도질병,전염성흔강、대인류건강구성실질성적위협.유우류감병독다변,림상상용우치료류감적약물도목전위지부유"체비"등유한적궤충.본문장문헌중이유보도적"체비"적합성로선회총병진행간요적종술.
Influenza is a highly infectious respiratory disease caused by virus, which in recent years has gradually become a substantial threat to the health of mankind. Because of the highly variable nature of the flu virus, chemotherapy of influenza has been very difficult. Up to now only a few drugs are available in the clinic treatment of influenza. In this review, synthetic routes to one of them, tamiflu, are surveyed.
