CAJ | 학술논문

1型糖尿病(T1DM)是遗传与环境因素共同作用所致的自身免疫性疾病.为预防和延缓T1DM高危人群自身免疫性胰岛炎的发生,阻止新发T1DM残存胰岛β细胞进一步遭受免疫破坏,T1DM的免疫防治有了较大进展.根据干预实施时机的不同,分为一级、二级和三级预防.主要通过饮食干预、自身抗原疫苗接种及单克隆抗体治疗等措施诱导自身免疫耐受,改善免疫调节,减少胰岛β细胞凋亡.许多临床研究对T1DM的免疫干预进行了探索,并进行了谷氨酸脱羧酶(GAD)疫苗、抗CD3单克隆抗体、DiaPep277等药物的临床研究,为T1DM的防治提供了新启示.
1형당뇨병(T1DM)시유전여배경인소공동작용소치적자신면역성질병.위예방화연완T1DM고위인군자신면역성이도염적발생,조지신발T1DM잔존이도β세포진일보조수면역파배,T1DM적면역방치유료교대진전.근거간예실시시궤적불동,분위일급、이급화삼급예방.주요통과음식간예、자신항원역묘접충급단극륭항체치료등조시유도자신면역내수,개선면역조절,감소이도β세포조망.허다림상연구대T1DM적면역간예진행료탐색,병진행료곡안산탈최매(GAD)역묘、항CD3단극륭항체、DiaPep277등약물적림상연구,위T1DM적방치제공료신계시.
Type 1 diabetes mellitus ( T1 DM) is an autoimmune disease attributed to both genetic and environmental factors.To prevent and delay autoimmune insulitis in population with high risk of T1DM,as well as to protect β cells from autoimmune destruction in recent-onset T1DM,the immunotherapy for the prevention and treatment of T1 DM has made a great progress.Three stages of intervention according to different situation are involved,which are primary,secondary and tertiary prevention.Treatment strategies aim to induce autoimmune tolerance,improve immune regulation and reduce β cells apoptosis through measures such as dietary intervention,self-antigen vaccine injection and monoclonal antibody therapy.Numbers of clinical trials explored the efficacy of immuno-intervention for T1DM,and evaluated glutamic acid decarboxylase ( GAD)vaccine,anti-CD3 monoclonal antibody and DiaPep277 therapy provide new promise for the treatment and prevention of T1 DM.