CAJ | 학술논문

生理情况下Notch通路不仅对成年神经干细胞数量的维持和自我更新发挥着决定性的作用,而且还可以抑制其向神经元分化,促进其向神经胶质细胞分化.脑缺血发生后,Notch信号通路被激活以调控缺血后脑损害区域的结构和功能重建.此文将主要综述Notch信号通路及其在生理和病理情况下对成年哺乳动物中枢神经系统的调控.
생리정황하Notch통로불부대성년신경간세포수량적유지화자아경신발휘착결정성적작용,이차환가이억제기향신경원분화,촉진기향신경효질세포분화.뇌결혈발생후,Notch신호통로피격활이조공결혈후뇌손해구역적결구화공능중건.차문장주요종술Notch신호통로급기재생리화병리정황하대성년포유동물중추신경계통적조공.
Physiologically, Notch signaling pathway is not only to be implicated in the maintenance and self-renewal of adult NSC, but also can inhibit differentiation of NSC to neuron and promotes to neural gila cells. After cerebral ischemia occurs, Notch signaling pathway is activated to regulate the reconstitution of the brain lesion and functional restoration. Here,we review the roles of Notch signaling pathway in the adult mammalian CNS in physiological and pathological conditions.