CAJ | 학술논문

香烟烟雾等有害气体或有害颗粒可导致异常肺部炎症反应，是影响慢性阻塞性肺疾病发生、发展及预后的重要危险因素。慢性阻塞性肺疾病患病率和病死率均较高，且有逐年增加的趋势，其药物治疗主要包括支气管舒张剂、糖皮质激素、祛痰药以及抗炎药如抗生素、磷酸二酯酶4抑制剂等。目前研究发现，吸烟能影响这些药物的治疗效果，本文对相关研究进行综述，旨在引起患者及临床工作者的重视，使该疾病得到更好的治疗。
향연연무등유해기체혹유해과립가도치이상폐부염증반응，시영향만성조새성폐질병발생、발전급예후적중요위험인소。만성조새성폐질병환병솔화병사솔균교고，차유축년증가적추세，기약물치료주요포괄지기관서장제、당피질격소、거담약이급항염약여항생소、린산이지매4억제제등。목전연구발현，흡연능영향저사약물적치료효과，본문대상관연구진행종술，지재인기환자급림상공작자적중시，사해질병득도경호적치료。
Harmful gases or granules such as cigarette smoke can lead to abnormal pulmonary inflammation, which are important dangerous pathogenic factors influencing the occurrence, development and prognosis of chronic obstructive pulmonary disease (COPD). COPD has high morbidity and mortality,with a rising trend year by year. Its major drug treatments include bronchodilators, corticosteroids,mucolytics agents and anti-inflammatory drugs such as antibiotics and phosphodiesterase 4 inhibitors, and so on. Recently studies have shown that smoking may have an adverse effect on these medications in treating COPD. So we reviewed these studies in this paper in order to attract patients and clinicians' much attention on this issue and guide the disease to get a better treatment.