CAJ | 학술논문

目的探讨三维适形放射不同剂量分割治疗晚期非小细胞肺癌( NSCLC)的近期疗效.方法 148例NSCLC随机采用三维适形放疗(3DCRT)(观察组,75例)和常规分割照射治疗(对照组,73例),观察近期疗效和不良反应,随访患者治疗后1、2、3年生存情况.结果对照组总有效47例(64.4％),观察组总有效60例(80.0％),两组差异有统计学意义(x2=4.50,P＜0.05).对照组1、2、3年生存率为50.7％、24.7％、8.2％,中位生存期为13个月；观察组分别为73.3％、45.3％、20.0％,中位生存期为19个月.两组生存率差异有统计学意义(x2=8.07、6,94、4.22,均P＜0.05).观察组血液系统副反应发生率明显低于对照组(x2=4.73,P＜0.05),两组急性放射性肺炎、放射性食管炎发生率差异无统计学意义(P＞0.05).结论 3 DC RT对晚期NSCLC近期疗效好,且治疗不良反应低,值得在临床上推广应用.
목적 탐토삼유괄형방사불동제량분할치료만기비소세포폐암( NSCLC)적근기료효.방법 148례NSCLC수궤채용삼유괄형방료(3DCRT)(관찰조,75례)화상규분할조사치료(대조조,73례),관찰근기료효화불량반응,수방환자치료후1、2、3년생존정황.결과 대조조총유효47례(64.4％),관찰조총유효60례(80.0％),량조차이유통계학의의(x2=4.50,P＜0.05).대조조1、2、3년생존솔위50.7％、24.7％、8.2％,중위생존기위13개월；관찰조분별위73.3％、45.3％、20.0％,중위생존기위19개월.량조생존솔차이유통계학의의(x2=8.07、6,94、4.22,균P＜0.05).관찰조혈액계통부반응발생솔명현저우대조조(x2=4.73,P＜0.05),량조급성방사성폐염、방사성식관염발생솔차이무통계학의의(P＞0.05).결론 3 DC RT대만기NSCLC근기료효호,차치료불량반응저,치득재림상상추엄응용.
Objective To explore the effect of three-dimensional conformal radiation dose fractionation treatment of advanced non-small cell lung cancer(NSCLC).Methods 75 NSCLC patients were treated with hypofractionated 3DCRT( observation group),while 73 cases were treated with conventional fractionated radiotherapy (control group).The efficacy and adverse reactions were observed;Survival after treatment were followed up in 1,2,3 years.Lung function was detected before and after radiotherapy treatment,including FVC,FEV1 and CLCO.Results The total effective cases of control group were 47 cases patients ( 64.4％ ),observation group's was 60 cases ( 80.0％ ),total effective rate had statistically significant difference ( x2 =4.50,P ＜ 0.05 ).Survival of control group after treatment in 1,2,3year were 50.7％,24.7％,8.2％,the median survival was 13 months,observation group's were 73.3％,45.3％,20.0％,and 19 months.The survival of these two groups was statistically different (x2 =8.07,6,94,4.22,all P ＜ 0.05 ).The patients blood system side effects of observation group were significantly lower than the control group ( x2 =4.73,P ＜0.05 ) ;acute radiation pneumonia,esophagitis of these two groups had no significant difference in the incidence( P ＞ 0.05 ).Conclusion Hypofractionated 3DCRT treatment of advanced NSCLC had good effect,and its adverse reactions was low,and it was worthy of clinical application.