CAJ | 학술논문

目的研究FLAG方案(氟达拉宾、阿糖胞苷和粒细胞集落刺激因子联合应用)治疗难治/复发急性髓细胞白血病的疗效和不良反应.方法 26例难治或复发性急性髓系白血病(难治15例,复发11例)患者接受FLAG方案治疗,包括氟达拉宾(Flud)30 mg·m-2·d-1,第1～5天;阿糖胞苷(Ara-C)1 000 mg/d,第1～5天;重组人粒细胞刺激因子(G-CSF)300μg/d,第0～5天.疗效评价标准为完全缓解(CR)、部分缓解(PR)、未缓解(NR).评估其疗效.结果 26例患者中14例达完全缓解(53.8%),5例部分缓解(19.2%),总有效率73.1%.该治疗方案毒副作用主要为骨髓抑制、中性粒细胞减少、消化道症状、轻度肝功能异常等.结论 FLAG方案治疗难治或复发AML疗效较好,副作用可以耐受,治疗相关病死率低,是难治或复发性AML首选治疗方案之一.
목적 연구FLAG방안(불체랍빈、아당포감화립세포집락자격인자연합응용)치료난치/복발급성수세포백혈병적료효화불량반응.방법 26례난치혹복발성급성수계백혈병(난치15례,복발11례)환자접수FLAG방안치료,포괄불체랍빈(Flud)30 mg·m-2·d-1,제1～5천;아당포감(Ara-C)1 000 mg/d,제1～5천;중조인립세포자격인자(G-CSF)300μg/d,제0～5천.료효평개표준위완전완해(CR)、부분완해(PR)、미완해(NR).평고기료효.결과 26례환자중14례체완전완해(53.8%),5례부분완해(19.2%),총유효솔73.1%.해치료방안독부작용주요위골수억제、중성립세포감소、소화도증상、경도간공능이상등.결론 FLAG방안치료난치혹복발AML료효교호,부작용가이내수,치료상관병사솔저,시난치혹복발성AML수선치료방안지일.
Objective To observe the therapeutic effects and side effects of FLAG regimen(fludarabine, Ara-C, and granulocyte-colony stimulating factor( C-CSF) for refractory or relapsed acute myeloid leukemia( AML). Methods Twenty-six AML were treated with fludarabine plus intermediate-dose Ara-C and G-CSF,of whom 15 cases belonged to refractory and 11 cases belonged to relapsed. Results After two courses of treatment, 14 cases were completely relieved (53. 8% ) and 5 cases were partially relieved (19.2% ). The overall effective rates was 73.1%. The main side effects were severe myelosuppression and non-hematological toxicity was mild. Conclusion FLAG regimen was very effective for refractory or relapsed acute myeloid leukemia and was well tolerated. The treatment-related mortality rate was low,so it provided a treatment choice for these patients.