CAJ | 학술논문

目的评价侧隐窝注射臭氧(O3)治疗腰椎间盘突出症致神经根炎对糖尿病患者血糖的影响.方法腰椎间盘突出症致神经根炎患者96例,糖尿病和非糖尿病患者各48例,糖尿病和非糖尿病患者分别采用随机数字表法各分为2组(n=24),非糖尿病-O3组(N-O3组)、非糖尿病-糖皮质激素组(N-GC组)和糖尿病-O3组(D-O3组)、糖尿病-糖皮质激素组(D-GC组).N-O3组和D-O3组分别于侧隐窝注射30 mg/L O3 10Ml,N-GC组和D-GC组分别于侧隐窝注射复方倍他米松注射液3.5 mg.于治疗前(T1)、治疗后1 h(T3)、4 h(T4)、治疗后1 d(T5)、3 d(T6)、7 d(T7)时测定血糖.于T1、治疗后即刻(T2)、T5、T6、T7时行VAS评分,于T1和T7时行健康调查简表评分,于T7时评定治疗效果,记录不良反应的发生情况.结果与T1时比较,4组治疗后VAS评分降低,T7时生理机能、躯体疼痛、情感职能、精神健康评分及N-GC组的一般健康状况评分、D-O3组和N-O3组的精力评分升高,N-GC组、D-O3组T4时及D-GC组T3～7时血糖升高(P＜0.05).N-O3组治疗前、后血糖比较差异无统计学意义(P＞0.05)；与N-O3组比较,N-GC组血糖升高(P＜0.05)；与D-O3组比较,D-GC组血糖升高(P＜0.05)；N-O3组、N-GC组及D-O组、D-GC组的优良率和健康调查简表各项评分比较差异无统计学意义(P＞0.05),且未见不良反应发生.结论侧隐窝注射O3治疗腰椎间盘突出症致神经根炎对糖尿病患者血糖无明显影响.
목적 평개측은와주사취양(O3)치료요추간반돌출증치신경근염대당뇨병환자혈당적영향.방법 요추간반돌출증치신경근염환자96례,당뇨병화비당뇨병환자각48례,당뇨병화비당뇨병환자분별채용수궤수자표법각분위2조(n=24),비당뇨병-O3조(N-O3조)、비당뇨병-당피질격소조(N-GC조)화당뇨병-O3조(D-O3조)、당뇨병-당피질격소조(D-GC조).N-O3조화D-O3조분별우측은와주사30 mg/L O3 10Ml,N-GC조화D-GC조분별우측은와주사복방배타미송주사액3.5 mg.우치료전(T1)、치료후1 h(T3)、4 h(T4)、치료후1 d(T5)、3 d(T6)、7 d(T7)시측정혈당.우T1、치료후즉각(T2)、T5、T6、T7시행VAS평분,우T1화T7시행건강조사간표평분,우T7시평정치료효과,기록불량반응적발생정황.결과 여T1시비교,4조치료후VAS평분강저,T7시생리궤능、구체동통、정감직능、정신건강평분급N-GC조적일반건강상황평분、D-O3조화N-O3조적정력평분승고,N-GC조、D-O3조T4시급D-GC조T3～7시혈당승고(P＜0.05).N-O3조치료전、후혈당비교차이무통계학의의(P＞0.05)；여N-O3조비교,N-GC조혈당승고(P＜0.05)；여D-O3조비교,D-GC조혈당승고(P＜0.05)；N-O3조、N-GC조급D-O조、D-GC조적우량솔화건강조사간표각항평분비교차이무통계학의의(P＞0.05),차미견불량반응발생.결론 측은와주사O3치료요추간반돌출증치신경근염대당뇨병환자혈당무명현영향.
Objective To evaluate the effect of injection of ozone (O3) through lateral recess for the treatment of radiculitis caused by lumbar disc herniation on the blood glucose in patients with diabetes mellitus.Methods Ninety-six patients with radiculitis caused by lumbar disc herniation involving 48 patients with diabetes mellitus and 48 patients without diabetes mellitus were enrolled in the study.The diabetic or non-diabetic patients were randomly divided into 2 groups ( n =24 each):non-diabetic patients-O3 group (group N-O3 ),non-diabetic patients-ghcocorticoid group (group N-GC),diabetic patients-O3 group (group D-O3 ),and diabetic patients-glucocorticoid group (group D-GC).In N-O3 and D-O3 groups,30 mg/L O3 10 ml was injected via the lateral recess.In N-GC and D-GC groups,compound betamethasone injection 3.5 mg was injected via the lateral recess.The blood glucose level was measured before treatment (T1),1 and 4 h after treatment (T3,4),and 1,3 and 7 days after treatment (T5-7).VAS score was recorded at T1,immediately after treatment (T2),and at T5-7.The patients' quality of life was measured using the Medical Outcomes Study 36-Item Short-Form Health Survey (MOS SF-36 Health Survey) questionnaire at T1,7.The therapeutic effect was evaluated at T7.The side effects were recorded.Results Compared with the baseline value at T1,VAS scores were significantly decreased after treatment,while the MOS SF-36 Health Survey questionnaire scores for physical functioning,bodily pain,role emotional,and mental health in all groups,for general health in group N-GC,and for vitality in groups D-O3 and N-O3 were significantly increased at T7,and the blood glucose level was significantly increased at T4 in groups N-GC and D-O3,and at T3-7 in group D-GC ( P ＜ 0.05).There was no significant change in the blood glucose level before and after treatment in group N-O3.The blood glucose level was significantly higher in group N-GC than in group N-O3,and in group D-GC than in group D-O3 ( P ＜ 0.05).There were no significant differences in the excellent and good rates and all the MOS SF-36 Health Survey questionnaire scores among all groups.No side effects were found in the study.Conclusion Injection of ozone through lateral recess for treatment of radiculitis caused by lumbar disc herniation exerts no influence on the blood glucose level in patients with diabetes mellitus.