CAJ | 학술논문

目的探讨肝炎肝硬化患者降钙素原(PCT)水平与肝功能的关系.方法用半定量固相免疫测定方法测定44例肝硬化患者血清PCT水平并检测ALT、AST、TBIL、ALB、CHE、CHOL、PTA等指标,并进行Child-pugh分级.结果以PCT＞0.5μg/L为阳性阈值,阳性组患者ALT、TBIL明显高于阴性组,CHOL、PTA明显低于阴性组.随着PCT水平的增加,ALT、AST、TBIL水平均逐渐升高,PTA逐渐下降.PCT阳性组以Child-pugh B、C级者为主,而PCT阴性组以Child-pugh B级者为主.患者PCT阳性者淋巴计数较PCT阴性者低.结论肝功能损伤使得肝硬化患者感染的风险增高,且随着损伤程度的加重,进展为重度感染危险逐渐增加.重视肝功能的保护,结合PCT水平的监测,有助于肝炎肝硬化患者感染的早期发现及控制.
목적 탐토간염간경화환자강개소원(PCT)수평여간공능적관계.방법 용반정량고상면역측정방법 측정44례간경화환자혈청PCT수평병검측ALT、AST、TBIL、ALB、CHE、CHOL、PTA등지표,병진행Child-pugh분급.결과 이PCT＞0.5μg/L위양성역치,양성조환자ALT、TBIL명현고우음성조,CHOL、PTA명현저우음성조.수착PCT수평적증가,ALT、AST、TBIL수평균축점승고,PTA축점하강.PCT양성조이Child-pugh B、C급자위주,이PCT음성조이Child-pugh B급자위주.환자PCT양성자림파계수교PCT음성자저.결론 간공능손상사득간경화환자감염적풍험증고,차수착손상정도적가중,진전위중도감염위험축점증가.중시간공능적보호,결합PCT수평적감측,유조우간염간경화환자감염적조기발현급공제.
Objective To explore the association between procalcitonin (PCT)levels and liver function in liver cirrhosis patients. Methods Collect serum samples from 44 liver cirrhosis patients, detect the PCT levels by semi-quantitative solid immunoassay, and at the same time, detect the serum levels of ALT, AST, TBIL, ALB, CHE, CHOL, PTA etc, then rate the patients by Child-pugh scoring system into Child-pugh A, B, C. Results set PCT ＞0. 5 μg/L as the positive threshold, significantly the PCT positive patients have higher ALT, TBIL but lower CHOL,PTA compared with the PCT negative patients. With the increasing of PCT levels,the ALT, AST, TBIL levels are gradually increased too, but PTA decreased. We find that the PCT positive patients are mainly Child-pugh B and C patients, and PCT negative patients are mainly Child-pugh C patients. PCT positive patient's lymphocyte count are lower than PCT negative patient's. Conclusion Liver injury increase the risk of infection in liver cirrhosis patients. As the severity of the injury, the patients are easier to progress into severe infection. Combined with monitoring the PCT levels, pay more attention to protect the liver function will be helpful in early detecting infections and controlling of infection in liver cirrhosis patients.