中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2012年
3期
54-56
,共3页
乌司他丁%危重症%全身炎性反应%多器官功能障碍综合征
烏司他丁%危重癥%全身炎性反應%多器官功能障礙綜閤徵
오사타정%위중증%전신염성반응%다기관공능장애종합정
Ulinastatin%Critical illness%Systemic inflammatory response%Multiple organ dysfunction syndrom
目的 观察乌司他丁在危重症治疗中的临床疗效.方法 42例危重症患者根据就诊时间分为两组,对照组20例采用常规治疗,治疗组22例在常规治疗的基础上静脉注射乌司他丁.观察记录两组治疗前后体温、心率、呼吸次数、白细胞计数、C-反应蛋白、尿素氮、肌酐、丙氨酸氨基转移酶、总胆红素、APACHEⅡ评分,以及呼吸机使用天数、肺泡-动脉氧分压差( AaDO2)及ICU住院天数.结果 治疗组体温、心率、呼吸次数、白细胞计数、C-反应蛋白、尿素氮、肌酐、丙氨酸氨基转移酶、总胆红素、APACHEⅡ评分、AaDO2改善情况显著优于对照组(P＜0.05),呼吸机使用天数、AaDO2和ICU住院天数较对照组明显缩短(P＜0.05).结论 乌司他丁在危重症治疗中的临床疗效比较好.
目的 觀察烏司他丁在危重癥治療中的臨床療效.方法 42例危重癥患者根據就診時間分為兩組,對照組20例採用常規治療,治療組22例在常規治療的基礎上靜脈註射烏司他丁.觀察記錄兩組治療前後體溫、心率、呼吸次數、白細胞計數、C-反應蛋白、尿素氮、肌酐、丙氨痠氨基轉移酶、總膽紅素、APACHEⅡ評分,以及呼吸機使用天數、肺泡-動脈氧分壓差( AaDO2)及ICU住院天數.結果 治療組體溫、心率、呼吸次數、白細胞計數、C-反應蛋白、尿素氮、肌酐、丙氨痠氨基轉移酶、總膽紅素、APACHEⅡ評分、AaDO2改善情況顯著優于對照組(P＜0.05),呼吸機使用天數、AaDO2和ICU住院天數較對照組明顯縮短(P＜0.05).結論 烏司他丁在危重癥治療中的臨床療效比較好.
목적 관찰오사타정재위중증치료중적림상료효.방법 42례위중증환자근거취진시간분위량조,대조조20례채용상규치료,치료조22례재상규치료적기출상정맥주사오사타정.관찰기록량조치료전후체온、심솔、호흡차수、백세포계수、C-반응단백、뇨소담、기항、병안산안기전이매、총담홍소、APACHEⅡ평분,이급호흡궤사용천수、폐포-동맥양분압차( AaDO2)급ICU주원천수.결과 치료조체온、심솔、호흡차수、백세포계수、C-반응단백、뇨소담、기항、병안산안기전이매、총담홍소、APACHEⅡ평분、AaDO2개선정황현저우우대조조(P＜0.05),호흡궤사용천수、AaDO2화ICU주원천수교대조조명현축단(P＜0.05).결론 오사타정재위중증치료중적림상료효비교호.
Objective To observe the clinical effect of ulinastatin(UTI) in treatment of patients with critical illness.Methods Forty-two patienLs with critical illness were randomly divided into two groups.Twenty cases in the control group were treated wiih normal therapy.Twenty-two cases in UTI group were treated with UTI through intravenous injection on the base of normal therapy.The changes of temperature( T),heart rate ( HR),respiration rate ( RR),white blood cell ( WBC),serum C-reactive protein( CRP),blood urea nitrogen( UREA),blood creatinine ( CRE),alanine transaminase( ALT),total bilirubin(TBIL) and APACHE Ⅱ score were compared in the two groups before and after the treatment.At the same time,the tolal time of mechanical ventilation,AaD02 and the total time in ICU were observed.Results The changes of T,HR,RR.WBC,CRP.UREA,CRE,ALT,TBIL and APACHE Ⅱ score in UTI group were significantly better than those in control group ( P ＜ 0.05).Moreover,there was obvious difference between the two groups in the total time of mechanical ventilation,AaDO2 and the total time in ICU ( P ＜ 0.05).Conclusions UTI is effective on patients with critical illness,and can be used in the treatment of critical illness.
