CAJ | 학술논문

目的研究急性脑梗死患者血清神经元特异性烯醇化酶(NSE)、S-100蛋白(S100B)、髓鞘碱性蛋白(MBP)浓度对其病情严重程度评估的价值.方法对62例急性脑梗死患者在病后72 h内进行血清NSE、S100B、MBP浓度检测,并结合神经功能缺损评分、脑梗死体积进行比较分析.结果本组62例脑梗死患者血清NSE、S100B、MBP浓度均显著高于正常对照组,而且病人中神经功能缺损程度不同组之间NSE、S100B、MBP浓度差异有统计学意义.分别以脑梗死后72 h血清NSE浓度20μg/L、S100B浓度1.0μg/L、MBP浓度8.0μg/L为临界标准评估病情严重程度,NSE特异度为70.00%,敏感度为70.27%;S100B的特异度为75.00%,敏感度为75.68%;MBP特异度为80.00%,敏感度为64.86%;另外,脑梗死体积越大,血清NSE、S100B、MBP浓度越高.结论脑梗死后血清NSE、S100B蛋白、MBP浓度对评估患者病情严重程度具有较高的特异性和敏感性.
목적 연구급성뇌경사환자혈청신경원특이성희순화매(NSE)、S-100단백(S100B)、수초감성단백(MBP)농도대기병정엄중정도평고적개치.방법 대62례급성뇌경사환자재병후72 h내진행혈청NSE、S100B、MBP농도검측,병결합신경공능결손평분、뇌경사체적진행비교분석.결과 본조62례뇌경사환자혈청NSE、S100B、MBP농도균현저고우정상대조조,이차병인중신경공능결손정도불동조지간NSE、S100B、MBP농도차이유통계학의의.분별이뇌경사후72 h혈청NSE농도20μg/L、S100B농도1.0μg/L、MBP농도8.0μg/L위림계표준평고병정엄중정도,NSE특이도위70.00%,민감도위70.27%;S100B적특이도위75.00%,민감도위75.68%;MBP특이도위80.00%,민감도위64.86%;령외,뇌경사체적월대,혈청NSE、S100B、MBP농도월고.결론 뇌경사후혈청NSE、S100B단백、MBP농도대평고환자병정엄중정도구유교고적특이성화민감성.
Objective To research the value of NSE,S100B and MBP concentration on predic-tion of severity of illness in patients with cerebral infarction. Methods The serum concentrations of NSE, S100B and MBP were measured within 72 hours after the injury in 62 cases of patients with cerebral infarction, then making a comparative analysis by neurologic impairment score and infarct volume. Re-suits The serum concentration of NSE,S100B and MBP after the injury in 62 patients with cerebral in-farction increased compared with those in the normal control group obviously. Moreover, there exists sig-nificant differences in the serum concentration of NSE,S100B and MBP between different groups that pa-tients were in different neurologic impairment score. To assess the severity of illness by serum concentra-tions of NSE 20 μg/L, S100B 1.0 μg/L and MBP 8.0 μg/L after 72 hours of cerebral infarction. Speci-ficity of NSE was 70.00%, sensitivity was 70.27% ; Specificity of S100B was 75.00%, sensitivity was 75.68% ; Specificity of MBP was 80.00%, sensitivity was 64.86%. In addition, the greater volume of cerebral infarction, the higher serum concentrations of NSE, S100B, MBP. Conclusions NSE, S100B and MBP may play important roles in predicting severity of illness in the patients with cerebral infarction.