怀化学院学报
懷化學院學報
부화학원학보
JOURNAL OF HUAIHUA TEACHERS COLLEGE
2004年
5期
46-50
,共5页
传递/不平衡检验(TDT)%"病例-父母"三人组%遗传印记效应%功效
傳遞/不平衡檢驗(TDT)%"病例-父母"三人組%遺傳印記效應%功效
전체/불평형검험(TDT)%"병례-부모"삼인조%유전인기효응%공효
transmission disequilibrium test (TDT)%case - parent trio%effect of genetic imprinting%power
根据Knapp在1999年提出的求TDT渐近功效的方法,应用标准的统计大样本理论,从两个方面对Knapp的方法进行了推广:(1)在疾病的遗传中考查了遗传印记的影响;(2)在求概率时考查了标记位点与候选疾病位点之间的位置关系.
根據Knapp在1999年提齣的求TDT漸近功效的方法,應用標準的統計大樣本理論,從兩箇方麵對Knapp的方法進行瞭推廣:(1)在疾病的遺傳中攷查瞭遺傳印記的影響;(2)在求概率時攷查瞭標記位點與候選疾病位點之間的位置關繫.
근거Knapp재1999년제출적구TDT점근공효적방법,응용표준적통계대양본이론,종량개방면대Knapp적방법진행료추엄:(1)재질병적유전중고사료유전인기적영향;(2)재구개솔시고사료표기위점여후선질병위점지간적위치관계.
According to the method proposed by Knapp in 1999 for computing the power of the transmission/disequilibrium test, the present article has applied standard statistical large- sample theory to extend the method proposed by Knapp from two aspects: (i) allowing for the effects of the genetic imprinting and (ii) the relation of psition between the marker locus and the disease susceptibility locus (DSL).
