CAJ | 학술논문

目的观察血液透析联合纳洛酮治疗急性重度酒精中毒的临床疗效.方法将108例急性重度酒精中毒患者随机分为两组:治疗组(55例)应用血液透析联合纳洛酮治疗,对照组(53例)单用纳洛酮治疗.对比两组患者治疗过程中意识恢复时间及并发症发生情况等.结果两组患者的治疗效果间差异有统计学意义(u=3.51,P<0.05).两组患者的意识恢复时间和症状消失时间间差异均有统计学意义(P<0.05).两组患者肾功能异常、肝功能异常、心肌损害和胰腺炎的发生率间差异均有统计学意义(P<0.05).结论应用血液透析联合纳洛酮救治急性重度酒精中毒,可缩短患者意识恢复时间,减少并发症,疗效明显优于单用纳洛酮.
목적 관찰혈액투석연합납락동치료급성중도주정중독적림상료효.방법 장108례급성중도주정중독환자수궤분위량조:치료조(55례)응용혈액투석연합납락동치료,대조조(53례)단용납락동치료.대비량조환자치료과정중의식회복시간급병발증발생정황등.결과 량조환자적치료효과간차이유통계학의의(u=3.51,P<0.05).량조환자적의식회복시간화증상소실시간간차이균유통계학의의(P<0.05).량조환자신공능이상、간공능이상、심기손해화이선염적발생솔간차이균유통계학의의(P<0.05).결론 응용혈액투석연합납락동구치급성중도주정중독,가축단환자의식회복시간,감소병발증,료효명현우우단용납락동.
Objective To study the therapeutic effect of hemodialysis combined with naloxone on acute severe alcoholism. Methods One hundred and eight patients with acute severe alcoholism were divided into groups treatment (n = 55, receiving hemodialysis with naloxone) and control ( n =53, receiving only naloxone). The time of consciousness recovery and complications were compared between two groups. Results There was significant difference in therapeutic effect between two groups (u = 3. 51, P<0. 05), and significant difference was noted in average time of consciousness recovery and symptom disappearance, and incidence of abnormal renal function, liver dysfunction, myocardial damage and pancreatitis (P < 0.05). Conclusion Combined hemodialysis and naloxone can shorten patients' consciousness recovery time, reduce complications and its therapeutic effect is superior to alone - used naloxone.