中国地方病学杂志
中國地方病學雜誌
중국지방병학잡지
CHINESE JOURNAL OF ENDEMIOLOGY
2009年
3期
291-293
,共3页
张立君%刘明法%陈洁%李少臣%裴俊瑞%周令望%刘阳%王铜%于维汉%梯保雄
張立君%劉明法%陳潔%李少臣%裴俊瑞%週令望%劉暘%王銅%于維漢%梯保雄
장립군%류명법%진길%리소신%배준서%주령망%류양%왕동%우유한%제보웅
克山病%谷胱甘肽过氧化物酶%心肌%玉米
剋山病%穀胱甘肽過氧化物酶%心肌%玉米
극산병%곡광감태과양화물매%심기%옥미
Keshan disease%Glutathione peroxidase%Myacardium%Corn
目的 探讨克山病病区玉米及酱块与大鼠心肌损伤的关系.方法 将雄性Wistar大鼠按体质量随机分为3组,分别饲以病区玉米、病区玉米+酱块、非病区玉米,1、3个月时检测大鼠尾静脉全血谷胱甘肽过氧化物酶(GSH-Px)活力,6个月时光镜下观察大鼠心肌病理改变.结果 1、3个月时3组大鼠全血GSH-Px活力比较,差异有统计学意义(F=23.60、72.46,P均<0.01),其中病区玉米组[(181.58±22.15)、(44.76±28.59)U/L]和病区玉米+酱块组[(195.03±17.66)、(30.38±3.35)U/L]明显低于非病区玉米组[(340.90±95.42)、(125.17±13.64)U/L,P均<0.01],而病区玉米组与病区玉米+酱块组比较,未见明显改变(P>0.05).光镜下3组大鼠心肌损伤病理改变发生率分别为3/9、1/9、2/7,组间比较差异无统计学意义(P>0.05).结论 单纯克山病病区玉米饲养可引起大鼠心肌损伤病理性改变,酱块无加重心肌损伤作用.
目的 探討剋山病病區玉米及醬塊與大鼠心肌損傷的關繫.方法 將雄性Wistar大鼠按體質量隨機分為3組,分彆飼以病區玉米、病區玉米+醬塊、非病區玉米,1、3箇月時檢測大鼠尾靜脈全血穀胱甘肽過氧化物酶(GSH-Px)活力,6箇月時光鏡下觀察大鼠心肌病理改變.結果 1、3箇月時3組大鼠全血GSH-Px活力比較,差異有統計學意義(F=23.60、72.46,P均<0.01),其中病區玉米組[(181.58±22.15)、(44.76±28.59)U/L]和病區玉米+醬塊組[(195.03±17.66)、(30.38±3.35)U/L]明顯低于非病區玉米組[(340.90±95.42)、(125.17±13.64)U/L,P均<0.01],而病區玉米組與病區玉米+醬塊組比較,未見明顯改變(P>0.05).光鏡下3組大鼠心肌損傷病理改變髮生率分彆為3/9、1/9、2/7,組間比較差異無統計學意義(P>0.05).結論 單純剋山病病區玉米飼養可引起大鼠心肌損傷病理性改變,醬塊無加重心肌損傷作用.
목적 탐토극산병병구옥미급장괴여대서심기손상적관계.방법 장웅성Wistar대서안체질량수궤분위3조,분별사이병구옥미、병구옥미+장괴、비병구옥미,1、3개월시검측대서미정맥전혈곡광감태과양화물매(GSH-Px)활력,6개월시광경하관찰대서심기병리개변.결과 1、3개월시3조대서전혈GSH-Px활력비교,차이유통계학의의(F=23.60、72.46,P균<0.01),기중병구옥미조[(181.58±22.15)、(44.76±28.59)U/L]화병구옥미+장괴조[(195.03±17.66)、(30.38±3.35)U/L]명현저우비병구옥미조[(340.90±95.42)、(125.17±13.64)U/L,P균<0.01],이병구옥미조여병구옥미+장괴조비교,미견명현개변(P>0.05).광경하3조대서심기손상병리개변발생솔분별위3/9、1/9、2/7,조간비교차이무통계학의의(P>0.05).결론 단순극산병병구옥미사양가인기대서심기손상병이성개변,장괴무가중심기손상작용.
Objective To investigate the myocardial damage in rats fed with corn from Keshan disease area added with bean puree. Methods Male Wistar rats were randomly divided into 3 groups according to their body weights, and fed with corn, corn from Keshan disease area added with bean puree, corn from non-endemic area. The GSH-Px activity of vena cardalis blood was examined in 1 and 3 months, rats were sacrificed after being fed for 6 months to examine the heart changes with HE stain. Results The three groups of GSH-Px activity were different in 1 and 3 months respectively(F=23.60,72.46, all P<0.01); GSH-Px activity was (181.58±22.15), (44.76±28.59)U/L in rats fed with corn, was (195.03±17.66), (30.38±3.35)U/L in those fed with corn added with bean puree from Keshan disease area, lower than the group fed with corn of non-endemic area[(340.90±95.42), (125.17±13.64)U/L, all P < 0.01]. But the difference of GSH-Px activity between simple corn group and corn adding bean puree groups of Keshan disease area was not obvious(P>0.05). Myocardial damage incidence of the three groups was 3/9,1/9,2/7. Difference among three groups did not have statistical significance(χ2=1.33, P> 0.05). Conclusions Only corn from Keshan disease area may induce myocardial damage pathology change. Adding bean puree into corn does not increase damage.
