中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2009年
7期
610-612
,共3页
刘兰芬%王丽娜%张敬悬%赵贵芳
劉蘭芬%王麗娜%張敬懸%趙貴芳
류란분%왕려나%장경현%조귀방
情感障碍%抑郁症%躁狂症%孤啡肽
情感障礙%抑鬱癥%躁狂癥%孤啡肽
정감장애%억욱증%조광증%고배태
Affective Disorder%Depression%Mania%Orphanin FQ
目的 探讨血浆孤啡肽(orphanin FQ,OFQ)水平与情感障碍的关系,为情感障碍的发病机制、诊断等寻找新的生物学指标.方法 筛选71例情感障碍患者(单相抑郁组24例、双相抑郁组21例、双相躁狂组26例)和31例正常人,应用放射免疫法分别测定其血浆OFQ水平,比较病例组与对照组血浆OFQ水平,分析病例组OFQ水平与各量表总分的相关性.结果 1.血浆孤啡肽水平:单相抑郁组为(17.20±4.13)ng/L,双相抑郁组为(20.16±3.58)ng/L,躁狂组为(11.29±3.28)ng/L,对照组为(13.92±4.53)ng/L.单、双相抑郁组OFQ水平明显高于对照组(t=2.76;t=5.28,均P<0.01);躁狂组OFQ水平明显低于对照组(t=2.47,P<0.05).2.单、双相抑郁组OFQ水平与汉密顿抑郁量表、蒙哥马利抑郁量表总分呈显著正相关(P<0.05),躁狂组OFQ水平与Beth-Rafaelsen躁狂量表总分呈显著负相关(P<0.01).结论 情感障碍患者血浆OFQ水平的变化可能参与情感障碍的发病机制并提示病情的严重程度.
目的 探討血漿孤啡肽(orphanin FQ,OFQ)水平與情感障礙的關繫,為情感障礙的髮病機製、診斷等尋找新的生物學指標.方法 篩選71例情感障礙患者(單相抑鬱組24例、雙相抑鬱組21例、雙相躁狂組26例)和31例正常人,應用放射免疫法分彆測定其血漿OFQ水平,比較病例組與對照組血漿OFQ水平,分析病例組OFQ水平與各量錶總分的相關性.結果 1.血漿孤啡肽水平:單相抑鬱組為(17.20±4.13)ng/L,雙相抑鬱組為(20.16±3.58)ng/L,躁狂組為(11.29±3.28)ng/L,對照組為(13.92±4.53)ng/L.單、雙相抑鬱組OFQ水平明顯高于對照組(t=2.76;t=5.28,均P<0.01);躁狂組OFQ水平明顯低于對照組(t=2.47,P<0.05).2.單、雙相抑鬱組OFQ水平與漢密頓抑鬱量錶、矇哥馬利抑鬱量錶總分呈顯著正相關(P<0.05),躁狂組OFQ水平與Beth-Rafaelsen躁狂量錶總分呈顯著負相關(P<0.01).結論 情感障礙患者血漿OFQ水平的變化可能參與情感障礙的髮病機製併提示病情的嚴重程度.
목적 탐토혈장고배태(orphanin FQ,OFQ)수평여정감장애적관계,위정감장애적발병궤제、진단등심조신적생물학지표.방법 사선71례정감장애환자(단상억욱조24례、쌍상억욱조21례、쌍상조광조26례)화31례정상인,응용방사면역법분별측정기혈장OFQ수평,비교병례조여대조조혈장OFQ수평,분석병례조OFQ수평여각량표총분적상관성.결과 1.혈장고배태수평:단상억욱조위(17.20±4.13)ng/L,쌍상억욱조위(20.16±3.58)ng/L,조광조위(11.29±3.28)ng/L,대조조위(13.92±4.53)ng/L.단、쌍상억욱조OFQ수평명현고우대조조(t=2.76;t=5.28,균P<0.01);조광조OFQ수평명현저우대조조(t=2.47,P<0.05).2.단、쌍상억욱조OFQ수평여한밀돈억욱량표、몽가마리억욱량표총분정현저정상관(P<0.05),조광조OFQ수평여Beth-Rafaelsen조광량표총분정현저부상관(P<0.01).결론 정감장애환자혈장OFQ수평적변화가능삼여정감장애적발병궤제병제시병정적엄중정도.
Objective To investigate the pathogenesis and diagnosis of affective disorder through studying the changes of plasma orphanin FQ (OFQ) level in patients with affective disorder. Methods 24 patients with major depressive disorder (M D group) ,21 patients with Bipolar Ⅱ depression (BD group ), 26 patients with Bipolar Ⅰ mania (BM group) and 31 healthy volunteers(control group)were studied. The concentrations of plasma orpha-nin FQ were measured by radioimmunoassay (RIA). Results 1. The plasma OFQ concentration was (17.20±4.13)ng/L in MD group, (20.16±3.58) ng/L in BD group, (11.29±3.28) ng/L in BM group and (13.92±4.53) ng/L in control group. Compared with the control group,the levels of plasma OFQ in MD and BD group were higher(t=2.76, t=5.28; P<0.01),while the level in BM group was lower( t=2.47, P<0.05). The differences were statistically significant. 2. The levels of plasma OFQ in MD and BD group were positively correla-ted to HAMD and MADRS( r = 0. 598, P <0.01;r=0.646, P < 0.05). And there was a significantly negative correlation between the OFQ level and BRMS in BM group( r= -0. 750, P<0.01 ). Conclusion The changes of plasma OFQ level may play an important role in the pathogenesis of affective disorder and indicate the severity of disease.
