中国临床实用医学
中國臨床實用醫學
중국림상실용의학
CHINA CLINICAL PRACTICAL MEDICINE
2009年
12期
96-98
,共3页
冠状动脉疾病%肺疾病%慢性阻塞性%比索洛尔%BODE指数
冠狀動脈疾病%肺疾病%慢性阻塞性%比索洛爾%BODE指數
관상동맥질병%폐질병%만성조새성%비색락이%BODE지수
Comnary disease%Pulmonary disease%Chronic obstructive%Bisoprolol%BODE index
目的 评价比索洛尔对冠心病合并慢性阻塞性肺疾病(COPD)患者BODE指数的影响.方法 42例冠心病合并稳定期轻、中度COPD患者,给予比索洛尔口服,起始剂量1.25 mg/d,逐步增加至5 mg/d.治疗开始前及治疗60 d后,分别检测BODE指数(BODE index)的四个相关参数,即第1秒用力呼气容积占预计值百分比((FEVI% pred)、功能性呼吸困难量表评分(MMRC)、6 min步行距离(6MWD)、体重指数(BMI),并计算BODE指数.结果 治疗前后BODE指数及其四个相关参数分别为:FEVI% pred(68.05±7.32 vs.67.38±7.13);6MWD(322.83±65.72 vs. 320.43±62.34);MMRC(2.13±0.57 vs.2.18±0.65);BMI(20.58±3.52 vs.20.26±3.07);BODE index(3.51±1.97 vs.3.54±2.01).(均为P>0.05).结论 比索洛尔对冠心病合并稳定期轻、中度COPD患者的BODE指数无明显影响.
目的 評價比索洛爾對冠心病閤併慢性阻塞性肺疾病(COPD)患者BODE指數的影響.方法 42例冠心病閤併穩定期輕、中度COPD患者,給予比索洛爾口服,起始劑量1.25 mg/d,逐步增加至5 mg/d.治療開始前及治療60 d後,分彆檢測BODE指數(BODE index)的四箇相關參數,即第1秒用力呼氣容積佔預計值百分比((FEVI% pred)、功能性呼吸睏難量錶評分(MMRC)、6 min步行距離(6MWD)、體重指數(BMI),併計算BODE指數.結果 治療前後BODE指數及其四箇相關參數分彆為:FEVI% pred(68.05±7.32 vs.67.38±7.13);6MWD(322.83±65.72 vs. 320.43±62.34);MMRC(2.13±0.57 vs.2.18±0.65);BMI(20.58±3.52 vs.20.26±3.07);BODE index(3.51±1.97 vs.3.54±2.01).(均為P>0.05).結論 比索洛爾對冠心病閤併穩定期輕、中度COPD患者的BODE指數無明顯影響.
목적 평개비색락이대관심병합병만성조새성폐질병(COPD)환자BODE지수적영향.방법 42례관심병합병은정기경、중도COPD환자,급여비색락이구복,기시제량1.25 mg/d,축보증가지5 mg/d.치료개시전급치료60 d후,분별검측BODE지수(BODE index)적사개상관삼수,즉제1초용력호기용적점예계치백분비((FEVI% pred)、공능성호흡곤난량표평분(MMRC)、6 min보행거리(6MWD)、체중지수(BMI),병계산BODE지수.결과 치료전후BODE지수급기사개상관삼수분별위:FEVI% pred(68.05±7.32 vs.67.38±7.13);6MWD(322.83±65.72 vs. 320.43±62.34);MMRC(2.13±0.57 vs.2.18±0.65);BMI(20.58±3.52 vs.20.26±3.07);BODE index(3.51±1.97 vs.3.54±2.01).(균위P>0.05).결론 비색락이대관심병합병은정기경、중도COPD환자적BODE지수무명현영향.
Objective To evaluate the effect of bisoprolol on BODE index in patients with coronary heart disease and concomitant chronic obstructive pulmonary disease(COPD).Methods Oral bisoprolol,with the initial dose of 1.25 mg/d,increased gradually to 5 mg/d,was administered to 42 cases of coronary heart disease patients complicated with stable mild to moderate COPD.Before the administration of bisoprolol and 60 days after,four relevant variables of BODE index,including FEV1% of predicted(FEV1% pred),the distance walked in 6 minutes(6MWD),score on the the MMRC dyspnea scale(MMRC)and Body mass index (BMI),were measured,and BODE index were constructed with the four variables above.Results Before and after the administration of bisoprolol,the results were:FEV1% pred(68.05±7.32 vs.67.38 ±7.13);6MWD(322.83±65.72 vs.320.43±62.34);MMRC(2.13±0.57 vs.2.18±0.65);BMI(20.58±3.52vs.20.26±3.07);BODE index(3.51±1.97 vs. 3.54±2.01).(all P>0.05).Conclusion Bisoprolol had no significant effect on BODE index in patients with coronary heart disease and concomitant stable mild to moderate COPD.
