CAJ | 학술논문

超氧化物歧化酶(superoxide dismutase,SOD)在维持生物体内超氧阴离子自由基产生与消除的动态平衡中起着重要的作用.铁超氧化物歧化酶(Fe-SOD)是原核生物和真核生物细胞器中专一的SOD酶,通过GenBank中搜集的原核生物Fe-SOD进行比对分析发现,Fe-SOD是相对保守的蛋白质,其中包含 2 个保守区域和 1 个可变区域,金属结合位点固定,Fe-SOD序列的比对可以反映物种间的进化关系,是研究原核生物分子进化的理想素材.
초양화물기화매(superoxide dismutase,SOD)재유지생물체내초양음리자자유기산생여소제적동태평형중기착중요적작용.철초양화물기화매(Fe-SOD)시원핵생물화진핵생물세포기중전일적SOD매,통과GenBank중수집적원핵생물Fe-SOD진행비대분석발현,Fe-SOD시상대보수적단백질,기중포함 2 개보수구역화 1 개가변구역,금속결합위점고정,Fe-SOD서렬적비대가이반영물충간적진화관계,시연구원핵생물분자진화적이상소재.
SOD (superoxide dismutase) plays an important role in the balance between the production and the elimination of superoxide anion free radical, Fe-SOD is a specific SOD enzyme in organelle of eukaryotic and prokaryotic organisms; It was found through comparison and analysis of eukaryotic Fe-SODs collected through GenBank that Fe-SODs are relatively conservative proteins, included 2 conservative domains and one variable domain with the fixed metal-linking site. Fe-SODs' sequence comparison could reflect the evolution relation among species, and they are an ideal source material to study the biomolecular evolution of prokaryotic of organisms.