中华航空航天医学杂志
中華航空航天醫學雜誌
중화항공항천의학잡지
CHINESE JOURNAL OF AEROSPACE MEDICINE
2009年
3期
186-191
,共6页
郑真%潘雪飞%江立红%梁谷米
鄭真%潘雪飛%江立紅%樑穀米
정진%반설비%강립홍%량곡미
脂肪肝%丙氨酸转氨酶%人体质量指数%超重%高脂血症%因素分析,统计学
脂肪肝%丙氨痠轉氨酶%人體質量指數%超重%高脂血癥%因素分析,統計學
지방간%병안산전안매%인체질량지수%초중%고지혈증%인소분석,통계학
Fatty liver%Alanine transaminase%Body mass index%Overweight%Hyperlipidemias%Factor analysis,statistical
目的 分析军事飞行人员非酒精性脂肪肝(NAFLD)流行状况和影响因素,为防治NAFLD提供依据.方法 调查飞行人员年龄、飞行年限、机种,测定体质指数(BMI),检测丙氨酸转氨酶(ALT)、天门冬氨酸氨基转移酶(AST)、γ-谷氨酰转移酶(GGT)、空腹血糖(FBG)、尿酸(UA)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C),及进行肝脏超声检查,根据有无NAFLD(分为2组)、BMI数值(分为2组)及ALT数值(分为3组)进行分组,并采用方差分析和Logistic回归分析处理数据.结果 426例男性飞行人员中,超重、NAFLD、ALT升高检出率分别为34.98%、19.48%和16.67%.超重组与体重正常组比较,NAFLD患病率、ALT异常率有显著差异(χ~2=145.152、58.959,P<0.01).与ALT<40 U/L组比较,40 U/L≤ALT<80 U/L组和ALT≥80 U/L组的BMI、TG,差异均有统计学意义(F=13.476、13.176,P<0.01).NAFLD组与对照组比较,年龄、飞行时间、BMI、ALT、AST、GGT、FBG、UA、TG、TC、LDL-C显著增高(t=2.287～7.002,P<0.05或0.01),而HDL-C水平显著降低(t=2.932,P<0.01).高速机种与低速机种组比较,年龄、飞行时间、BMI、ALT、AST、GGT、FBG、UA、TC、TG、HDL-C、LDL-C及NAFLD发病率差异均无统计学意义.单因素Logistic回归分析显示显著影响NAFLD的变量为BMI、TG和飞行机种(Z=37.353、8.658、4.486,P<0.05或0.01).结论 飞行人员NAFLD患病率偏高,存在超重、血脂异常等危险因素,早期发现并治疗NAFLD是阻止其发展及预防心脑血管事件的重要措施之一.
目的 分析軍事飛行人員非酒精性脂肪肝(NAFLD)流行狀況和影響因素,為防治NAFLD提供依據.方法 調查飛行人員年齡、飛行年限、機種,測定體質指數(BMI),檢測丙氨痠轉氨酶(ALT)、天門鼕氨痠氨基轉移酶(AST)、γ-穀氨酰轉移酶(GGT)、空腹血糖(FBG)、尿痠(UA)、總膽固醇(TC)、甘油三酯(TG)、高密度脂蛋白膽固醇(HDL-C)、低密度脂蛋白膽固醇(LDL-C),及進行肝髒超聲檢查,根據有無NAFLD(分為2組)、BMI數值(分為2組)及ALT數值(分為3組)進行分組,併採用方差分析和Logistic迴歸分析處理數據.結果 426例男性飛行人員中,超重、NAFLD、ALT升高檢齣率分彆為34.98%、19.48%和16.67%.超重組與體重正常組比較,NAFLD患病率、ALT異常率有顯著差異(χ~2=145.152、58.959,P<0.01).與ALT<40 U/L組比較,40 U/L≤ALT<80 U/L組和ALT≥80 U/L組的BMI、TG,差異均有統計學意義(F=13.476、13.176,P<0.01).NAFLD組與對照組比較,年齡、飛行時間、BMI、ALT、AST、GGT、FBG、UA、TG、TC、LDL-C顯著增高(t=2.287～7.002,P<0.05或0.01),而HDL-C水平顯著降低(t=2.932,P<0.01).高速機種與低速機種組比較,年齡、飛行時間、BMI、ALT、AST、GGT、FBG、UA、TC、TG、HDL-C、LDL-C及NAFLD髮病率差異均無統計學意義.單因素Logistic迴歸分析顯示顯著影響NAFLD的變量為BMI、TG和飛行機種(Z=37.353、8.658、4.486,P<0.05或0.01).結論 飛行人員NAFLD患病率偏高,存在超重、血脂異常等危險因素,早期髮現併治療NAFLD是阻止其髮展及預防心腦血管事件的重要措施之一.
목적 분석군사비행인원비주정성지방간(NAFLD)류행상황화영향인소,위방치NAFLD제공의거.방법 조사비행인원년령、비행년한、궤충,측정체질지수(BMI),검측병안산전안매(ALT)、천문동안산안기전이매(AST)、γ-곡안선전이매(GGT)、공복혈당(FBG)、뇨산(UA)、총담고순(TC)、감유삼지(TG)、고밀도지단백담고순(HDL-C)、저밀도지단백담고순(LDL-C),급진행간장초성검사,근거유무NAFLD(분위2조)、BMI수치(분위2조)급ALT수치(분위3조)진행분조,병채용방차분석화Logistic회귀분석처리수거.결과 426례남성비행인원중,초중、NAFLD、ALT승고검출솔분별위34.98%、19.48%화16.67%.초중조여체중정상조비교,NAFLD환병솔、ALT이상솔유현저차이(χ~2=145.152、58.959,P<0.01).여ALT<40 U/L조비교,40 U/L≤ALT<80 U/L조화ALT≥80 U/L조적BMI、TG,차이균유통계학의의(F=13.476、13.176,P<0.01).NAFLD조여대조조비교,년령、비행시간、BMI、ALT、AST、GGT、FBG、UA、TG、TC、LDL-C현저증고(t=2.287～7.002,P<0.05혹0.01),이HDL-C수평현저강저(t=2.932,P<0.01).고속궤충여저속궤충조비교,년령、비행시간、BMI、ALT、AST、GGT、FBG、UA、TC、TG、HDL-C、LDL-C급NAFLD발병솔차이균무통계학의의.단인소Logistic회귀분석현시현저영향NAFLD적변량위BMI、TG화비행궤충(Z=37.353、8.658、4.486,P<0.05혹0.01).결론 비행인원NAFLD환병솔편고,존재초중、혈지이상등위험인소,조기발현병치료NAFLD시조지기발전급예방심뇌혈관사건적중요조시지일.
Objective To analyze the pathogenetic status and risk factors of nonalcoholic fatty liver disease (NAFLD) in military airerews, in order to provide evidence for the treatment and prevention of NAFLD. Methods The study included collecting data as military airerew's age, flying hours and type of aircraft, calculating body mass index (BMI), measuring liver function [alanine transaminase (ALT), aspartase aminotransferase (AST), gamma-glutamyltransferase (GGT)], fasting blood glucose (FBG), uric acid (UA), total cholesterol (TC), triglyceride(TG), high density lipoprotein-cholesterol (HDL-C) and low density lipoprotein-cholesterol (HDL-C), as well as examining liver by B-ultrasound. Results were processed by variance and Logistic regression analysis according to the groups that respectively divided by NAFLD (2 groups), BMI value (2 groups) and ALT value (3 groups by the ranges within ALT<40 U/L, 40 U/L≤ALT<80 U/L and ALT≥ U/L). Results Out of 426 male aircrews, 34.98% were overweight, 19.48% had NAFLD and 16.67% were with high ALT. Compared with normal weight group, morbidity rate of NAFLD and level of ALT were significantly higher than those in over weight group (χ~2=145.152, 58.959, P< 0.01). Aircrews in ALT≥40 U/L group showed statistical differences on BMI and TG compared to those in ALT<40 U/L group (F=13.476, 13.176, P<0.01). ATL, AST, C, GT, TG, TC, LDL-C, FBG and UA in NAFLD group were significantly higher than those in control group (t= 2.287-7.002, P<0.05 or 0.01), but HDL-C level was significantly lower (t=2.932, P<0.01). There were no statistical differences between fast jet and low speed aircraft (transporter, bomber, helicopter, etc.) aircrews in age, flying hours, BMI and other biochemical indexes. Logistic regression analysis showed that the factors that induced NAFLD were BMI, TG and type of aircraft (Z=37.353, 8.658, 4.486, P<0.05 or 0.01). Conclusions The aircrews have higher morbidity rate of NAFLD with such high risk factors as over weight, high blood lipid (high TG, high LDL-C and low HDLC). So early diagnosis and treatment of NAFLD would be one of the most important measures for limiting its growth and preventing cardiovascular and cerebrovaseular diseases.
