CAJ | 학술논문

目的探讨桥本甲状腺炎合并甲状腺癌的临床病理特点及两者的关系.方法对48例桥本甲状腺炎和其中9例合并甲状腺癌的临床病理资料进行回顾性分析.结果桥本甲状腺炎合并甲状腺癌的平均发病年龄45.2岁,女性多于男性.48例桥本甲状腺炎中9例合并甲状腺癌,且均为乳头状癌,占桥本甲状腺炎的18.8%,其中微小乳头状癌5例,经典型2例,滤泡型1例,嗜酸细胞型1例.癌旁甲状腺组织内多数可见滤泡上皮增生、乳头状增生、不典型增生至癌变的移行状态.其癌组织的镜下形态学表现与单纯甲状腺乳头状癌相似.结论桥本甲状腺炎合并甲状腺癌发生率高,两者关系密切,好发于中年女性,多无临床症状.桥本甲状腺炎是一种具有恶性潜能的病变,应引起高度重视,并仔细检查.
목적 탐토교본갑상선염합병갑상선암적림상병리특점급량자적관계.방법 대48례교본갑상선염화기중9례합병갑상선암적림상병리자료진행회고성분석.결과 교본갑상선염합병갑상선암적평균발병년령45.2세,녀성다우남성.48례교본갑상선염중9례합병갑상선암,차균위유두상암,점교본갑상선염적18.8%,기중미소유두상암5례,경전형2례,려포형1례,기산세포형1례.암방갑상선조직내다수가견려포상피증생、유두상증생、불전형증생지암변적이행상태.기암조직적경하형태학표현여단순갑상선유두상암상사.결론 교본갑상선염합병갑상선암발생솔고,량자관계밀절,호발우중년녀성,다무림상증상.교본갑상선염시일충구유악성잠능적병변,응인기고도중시,병자세검사.
Objective To investigate the clinicopathological features of coexistent Hashimoto's thyroiditis(HT) with thyroid carcinoma(TC) .Methods The clinicopathological data of 48 cases of HT and 9 cases of coexistent HT with TC from 1996 to 2008 were reviewed.Results The mean age was 45.2 years old. Female cases were more than male. In total 48 cases of HT, 9 cases had coexistent TC that was papillary thyroid carcinoma. The coexistent rate of HT with TC was 18.8%. Histological classification showed that 5 cases of papillary microcarcinoma, 2 classic variant, 1 follicular variant, and 1 oxyphilic cell variant. The transformation froms of follicular epithelial cell hyperplasia, to papillary hyperplasia to atypical hyperplasia and to carcinomatous change were observed in the tissues of coexistent HT with TC. Microscopic morphology of carcinomatous tissue of coexistent HT with TC was similar to that of ordinary papillary thyroid carcinoma.Conclusion There is a high coexistent rate of HT with TC. HT is closely associated with TC. Coexistent HT with TC occurs preferentially in the group of middle-aged women with no clinical symptom. HT is a potential malignant disease, and it should be paid more attention to, and multiple sampling in suspected area of HT specimen is recommended in order to miss any small tumor in clinical practice.