CAJ | 학술논문

目的研究单纯性肥胖患者短期内体质量剧烈波动导致的胰岛素抵抗变化.方法采用前瞻性自身对照研究.研究对象为94例女性单纯肥胖患者,BMI≥28 kg/m2.予低热量低碳水化合物低脂高蛋白饮食+拔罐或针灸治疗2个月,在基线、2个月、6个月和12个月测量体质量、BMI、腰围、臀围、血糖、血胰岛素,评价胰岛素抵抗情况.结果经减肥治疗2个月,83例患者体质量、BMI、腰围、臀围、空腹胰岛素、HOMAIR指数均显著下降(P＜0.01或P＜0.05).6个月随访时,这些指标有反弹趋势.12个月时体质量、BMI、腰围、臀围恢复至基线水平;其中44%患者体质量反弹,空腹胰岛素水平、HOMA-IR指数显著性升高(P＜0.05).结论低热量低碳水化合物低脂高蛋白饮食+拔罐或针灸治疗可以有效治疗肥胖,但12月随访时部分患者体质量反弹,并且导致追赶生长和胰岛素抵抗情况加重.
목적 연구단순성비반환자단기내체질량극렬파동도치적이도소저항변화.방법 채용전첨성자신대조연구.연구대상위94례녀성단순비반환자,BMI≥28 kg/m2.여저열량저탄수화합물저지고단백음식+발관혹침구치료2개월,재기선、2개월、6개월화12개월측량체질량、BMI、요위、둔위、혈당、혈이도소,평개이도소저항정황.결과 경감비치료2개월,83례환자체질량、BMI、요위、둔위、공복이도소、HOMAIR지수균현저하강(P＜0.01혹P＜0.05).6개월수방시,저사지표유반탄추세.12개월시체질량、BMI、요위、둔위회복지기선수평;기중44%환자체질량반탄,공복이도소수평、HOMA-IR지수현저성승고(P＜0.05).결론 저열량저탄수화합물저지고단백음식+발관혹침구치료가이유효치료비반,단12월수방시부분환자체질량반탄,병차도치추간생장화이도소저항정황가중.
Objective To study the changes of insulin resistance due to severe short-term fluctuations of body mass in simple obese patients. Methods 94 women with simple obesity, were treated by low caloric and high protein diet for two months. A series of examinations were taken before and after the treatment. Results After two months, weight, body mass index (BMI), waist, hip, fasting serum insulin and HOMA-IR reduced significantly ( P <0. 01 or P < 0.05 ). But after 6 months follow-up,these data began to regain. After 12 months ,these data were not significantly different. Fasting serum insulin and HOMA-IR increased ( P < 0. 05). Conclusions The low caloric and high protein diet combined acupuncture or cupping could reduce weight. But 44% patients weight rebound, and HOMA-IR increased.