中华神经医学杂志
中華神經醫學雜誌
중화신경의학잡지
CHINESE JOURNAL OF NEUROMEDICINE
2012年
3期
269-272
,共4页
白细胞介素-6%白细胞介素-8%肿瘤坏死因子α%急性脑梗死%相关性
白細胞介素-6%白細胞介素-8%腫瘤壞死因子α%急性腦梗死%相關性
백세포개소-6%백세포개소-8%종류배사인자α%급성뇌경사%상관성
IL-6%IL-8%TNT-α%Acute cerebral infarction%Correlation
目的 探讨血清中炎性细胞因子与高血压致急性脑梗死(ACI)的相关性. 方法 选择河北医科大学第三医院心血管一科和神经内科自2007年6月至2009年6月收治的ACI并高血压患者102例(其中小体积梗死30例,中体积梗死45例,大体积梗死27例)和单纯ACI患者30例,同期门诊健康体检正常者30例作为对照组,ELISA检测ACI并高血压组患者入院第1、3、5、7、14天,单纯ACI组、对照组入院第1天血清细胞介素6(IL-6)、白细胞介素-8(IL-8)、肿瘤坏死因子α(TNF-α)水平,分析血清IL-6、IL-8、TNF-α水平与ACI体积的相关性. 结果 入院第1天ACI并高血压组、单纯ACI组、对照组血清IL-6、IL-8、TNF-α水平均依次降低,差异有统计学意义(P＜0.05).第1、3、5、7天对照组、小体积梗死组、中体积梗死组、大体积梗死组血清IL-6、IL-8及TNF-α水平依次升高,差异均有统计学意义(P<0.05).第14天4组TNF-α水平依次升高,差异有统计学意义(P＜0.05)；ACI并高血压患者血清IL-6、IL-8水平在第1、3、5、7天与ACI体积呈正相关关系,TNF-α水平在在第1、3、5、7、14天与ACI体积呈正相关关系. 结论 IL-6、IL-8、TNF-α水平与高血压对ACI的发病有协同作用,ACI并高血压患者血清IL-6、IL-8、TNF-α水平与脑梗死的体积相关.
目的 探討血清中炎性細胞因子與高血壓緻急性腦梗死(ACI)的相關性. 方法 選擇河北醫科大學第三醫院心血管一科和神經內科自2007年6月至2009年6月收治的ACI併高血壓患者102例(其中小體積梗死30例,中體積梗死45例,大體積梗死27例)和單純ACI患者30例,同期門診健康體檢正常者30例作為對照組,ELISA檢測ACI併高血壓組患者入院第1、3、5、7、14天,單純ACI組、對照組入院第1天血清細胞介素6(IL-6)、白細胞介素-8(IL-8)、腫瘤壞死因子α(TNF-α)水平,分析血清IL-6、IL-8、TNF-α水平與ACI體積的相關性. 結果 入院第1天ACI併高血壓組、單純ACI組、對照組血清IL-6、IL-8、TNF-α水平均依次降低,差異有統計學意義(P＜0.05).第1、3、5、7天對照組、小體積梗死組、中體積梗死組、大體積梗死組血清IL-6、IL-8及TNF-α水平依次升高,差異均有統計學意義(P<0.05).第14天4組TNF-α水平依次升高,差異有統計學意義(P＜0.05)；ACI併高血壓患者血清IL-6、IL-8水平在第1、3、5、7天與ACI體積呈正相關關繫,TNF-α水平在在第1、3、5、7、14天與ACI體積呈正相關關繫. 結論 IL-6、IL-8、TNF-α水平與高血壓對ACI的髮病有協同作用,ACI併高血壓患者血清IL-6、IL-8、TNF-α水平與腦梗死的體積相關.
목적 탐토혈청중염성세포인자여고혈압치급성뇌경사(ACI)적상관성. 방법 선택하북의과대학제삼의원심혈관일과화신경내과자2007년6월지2009년6월수치적ACI병고혈압환자102례(기중소체적경사30례,중체적경사45례,대체적경사27례)화단순ACI환자30례,동기문진건강체검정상자30례작위대조조,ELISA검측ACI병고혈압조환자입원제1、3、5、7、14천,단순ACI조、대조조입원제1천혈청세포개소6(IL-6)、백세포개소-8(IL-8)、종류배사인자α(TNF-α)수평,분석혈청IL-6、IL-8、TNF-α수평여ACI체적적상관성. 결과 입원제1천ACI병고혈압조、단순ACI조、대조조혈청IL-6、IL-8、TNF-α수평균의차강저,차이유통계학의의(P＜0.05).제1、3、5、7천대조조、소체적경사조、중체적경사조、대체적경사조혈청IL-6、IL-8급TNF-α수평의차승고,차이균유통계학의의(P<0.05).제14천4조TNF-α수평의차승고,차이유통계학의의(P＜0.05)；ACI병고혈압환자혈청IL-6、IL-8수평재제1、3、5、7천여ACI체적정정상관관계,TNF-α수평재재제1、3、5、7、14천여ACI체적정정상관관계. 결론 IL-6、IL-8、TNF-α수평여고혈압대ACI적발병유협동작용,ACI병고혈압환자혈청IL-6、IL-8、TNF-α수평여뇌경사적체적상관.
Objective To investigate the correlations between serum levels of IL-6,IL-8 and TNF-α and acute cerebral infarction (ACI) caused by hypertension. Methods This study enrolled 102patients with hypertensive ACI (group A),30 patients with simple ACI (group B) and 30 healthy adults (group C) who sought medical intervention or check-up in our hospital between June 2007 and June 2009.Group A was further divided into 3 sub-groups by the infarction volume (30 cases in the small subgroup,45 cases in the intermediate subgroup and 27 cases in the large subgroup).The serum levels of IL-6,IL-8 and TNF-α in groups A,B and C were measured on 1,3,5,7,14 days post-admission and compared.The correlation of the serum levels of IL-6,IL-8 and TNF-α with the infarction volumes in group A was analyzed. Results The serum levels of IL-6,IL-8 and TNF-α decreased significantly on the first day post-admission from group A to group C (P＜0.05).The serum levels of IL-6,IL-8 and TNF-αsignificantly increased,in turn,from group C,the small subgroup,the intermediate subgroup to the large subgroup on 1, 3, 5, 7, 14 days post-admission except for the levels of IL-6 and IL-8 on 14 days post-admission (P＜0.05).In group A,the serum levels of IL-6 and IL-8 were positively correlated with the infarction volume on 1,3,5, 7 days post-admission while the serum level of TNF-α was positively correlated with the infarction volume on 1,3,5,7,14 days post-admission. Conclusions IL-6,IL-8,TNT-α and hypertension play a joint role in cerebral infarction.Serum levels of IL-6,IL-8 and TNT-α are closely related to the volume of cerebral infarction in ACI patients.
