CAJ | 학술논문

目的:研究20(R)-人参皂甙Rg3人体药代动力学.方法:高效液相色谱一紫外检测法.结果:8名健康志愿者单剂量口服3.2 mg@kg-1 20(R)-人参皂甙Rg3,其药时曲线符合口服吸收有滞后时间的二房室模型,Tmax为0.66±0.10 h,Cmax为16±6 ng@mL-1,Tinα为0.46±0.12 h,T1/2β为4.9±1.1 h,T1/2(Ka)为0.28±0.04 h,AUC0-∞为77±26 ng@mL-1@h;6名健康志愿者单剂量口服0.8 mg@kg-1 Rg3,由于血药浓度低,可测数据点少,未进行模型模拟;两组给药剂量与相应Cmax实测值比较,二者成正比关系.结论:本品口服吸收快,消除也较快,但血药浓度很低.在所试剂量范围内,20(R)-人参皂甙Rg3属一级动力学吸收、消除过程.
목적:연구20(R)-인삼조대Rg3인체약대동역학.방법:고효액상색보일자외검측법.결과:8명건강지원자단제량구복3.2 mg@kg-1 20(R)-인삼조대Rg3,기약시곡선부합구복흡수유체후시간적이방실모형,Tmax위0.66±0.10 h,Cmax위16±6 ng@mL-1,Tinα위0.46±0.12 h,T1/2β위4.9±1.1 h,T1/2(Ka)위0.28±0.04 h,AUC0-∞위77±26 ng@mL-1@h;6명건강지원자단제량구복0.8 mg@kg-1 Rg3,유우혈약농도저,가측수거점소,미진행모형모의;량조급약제량여상응Cmax실측치비교,이자성정비관계.결론:본품구복흡수쾌,소제야교쾌,단혈약농도흔저.재소시제량범위내,20(R)-인삼조대Rg3속일급동역학흡수、소제과정.
Objective: To study the pharmacokinetics of 20(R)-Ginsenoside Rg3 in the human body.Methods: High-performance liquid chromatography-ultraviolet detection method was used in this study. Results:The pharmacokinetics of Ginsenoside Rg3 in 14 healthy volunteers were investigated. After a single oral dose of 3.2mg@kg-1 Ginsenoside Rg3 in 8 male volunoeers,the plasma concentration-time course fitted in well with a twocompartment open model,with the following pharmacokinetic parameters: Tmax 0.66±0.10 h,Cmax 16±6 ng.mL-1,Tv2α0.46±0.12 h,T1/2β 4.9±1.1 h,T1/2(Ka) 0.28±0.04 h,AUC0.∞ 77±26 ng@mL-1@h,respectively. No kinetic analysis was made after an oral dose of 0.8 mg@kg-1 Rg3 in other 6 volunteers because of the low concentration,but there was a good correlation between Cmax and dosage of the two groups. Conclusion: The absorption of Rg3 was rapid in the human body,and its elimination was rapid too after oral administration of Ginsenoside Rg3. The pharmacokinetic results shows that it exhibited the first-order kinetic characteristics.