CAJ | 학술논문

化学合成成分实时监测技术是一种新颖的化学过程分析方法,可对化学合成成分进行实时动态监测,揭示化学反应发生的微观机理、反应历程和动力学特征,合理确定反应终点,提高反应的选择性、产物质最和收率.阐述了实时监测技术基本结构与原理,综述了实时监测技术在化学合成成分分析中的应用,着重评价了光谱法、色谱法及其联用技术在化学合成成分实时监测中的研究、开发和进展.采用联用技术可发挥色谱的高效分离和定最特性以及光谱灵敏的定性鉴别能力,以实现埘复杂体系中特定成分的实时监控.随着微处理器和嵌入式系统的研制,化学合成成分实时分析技术将向微型化、智能化、数字化、功能化且通用性广、兼容性强的多通道组分监测方向发展.
화학합성성분실시감측기술시일충신영적화학과정분석방법,가대화학합성성분진행실시동태감측,게시화학반응발생적미관궤리、반응역정화동역학특정,합리학정반응종점,제고반응적선택성、산물질최화수솔.천술료실시감측기술기본결구여원리,종술료실시감측기술재화학합성성분분석중적응용,착중평개료광보법、색보법급기련용기술재화학합성성분실시감측중적연구、개발화진전.채용련용기술가발휘색보적고효분리화정최특성이급광보령민적정성감별능력,이실현시복잡체계중특정성분적실시감공.수착미처리기화감입식계통적연제,화학합성성분실시분석기술장향미형화、지능화、수자화、공능화차통용성엄、겸용성강적다통도조분감측방향발전.
Real-time monitoring technique for process parameters and/or insight variables of chemical synthetic ingredients is a novel chemical process analysis method,which can real time monitor the chemical synthetic ingredients,reveal the mechanism of chemical reaction occurring,reaction courses and kinetic characteristics,and monitor,control and adjust chemical reaction to determine the endpoint of reaction and enhance selectivity of reaction,quality and yields of product.Many real-time monitoring techniques were achieved to satisfy the demands in several chemical synthetic reactions.The structure and principles of current real-time monitoring techniques was stated,and a review was summarized on its applications in chemical synthetic ingredients.The research,development and applications of real-time monitoring techniques such as spectrometry(i.e.ultraviolet-visible spectrophotometry,infrared spectrometry,Raman spectroscopy,nuclear magnetic resonance spectroscopy,mass spectrometry and fluorescence spectroscopy),chromatography(i.e.thin layer chromatography,gas chromatography,high performance liquid chromatography and capillary electrophoresis)and their coupled techniques(i.e.GC-MS,GC-IR and LC-MS)for chemical synthetic ingredients were evaluated.The coupled techniques were utilized to take the advantages of their high performance separation and quantitative power of chromatography,and sensitive and qualitative identification capacity of spectrometric techniques could realize the real-time monitoring for special chemical synthetic ingredients in complex systems.The future developmental trends and application prospects of real-time monitoring techniques are also discussed.With the research & development of microprocessor and embedded system,the real-time monitoring instrument for chemical synthetic ingredients will have a trend to miniaturization,intelligence,digitization,functionalization and multiehannel with widely versatile and strongly compatible features.