CAJ | 학술논문

选用健康家犬6只,按随机交叉设计试验,单剂量给药均为每千克体重2.75 mg,用高效液相色谱法测定血药浓度,并应用3P97计算药物动力学参数.结果肌肉注射与口服麻保沙星的药时数据符合一级吸收一室开放模型,主要药物动力学参数如下:T_(1/2ka)(吸收半衰期)分别为(0.52±0.41) h和(0.41±0.13) h,T_(1/2ke)(消除半衰期)为(4.40±1.86) h和(6.25±1.80) h,T_(peak)(峰时间)为(1.53±0.75) h和(1.68±0.39) h,C_(max)(峰浓度)为(1.36±0.38)μg/mL和(0.93±0.06)μg/mL,AUC(药时曲线下面积)为(10.64±2.66) (μg·h)/mL和(8.68±1.98) (μg·h)/mL.乳酸麻保沙星在健康家犬口服与注射给药吸收迅速,表观分布容积大,消除缓慢,口服给药较肌肉注射吸收后分布的组织更深更广.
선용건강가견6지,안수궤교차설계시험,단제량급약균위매천극체중2.75 mg,용고효액상색보법측정혈약농도,병응용3P97계산약물동역학삼수.결과기육주사여구복마보사성적약시수거부합일급흡수일실개방모형,주요약물동역학삼수여하:T_(1/2ka)(흡수반쇠기)분별위(0.52±0.41) h화(0.41±0.13) h,T_(1/2ke)(소제반쇠기)위(4.40±1.86) h화(6.25±1.80) h,T_(peak)(봉시간)위(1.53±0.75) h화(1.68±0.39) h,C_(max)(봉농도)위(1.36±0.38)μg/mL화(0.93±0.06)μg/mL,AUC(약시곡선하면적)위(10.64±2.66) (μg·h)/mL화(8.68±1.98) (μg·h)/mL.유산마보사성재건강가견구복여주사급약흡수신속,표관분포용적대,소제완만,구복급약교기육주사흡수후분포적조직경심경엄.
Pharmacokinetics of two different forms of marbofloxacin was investigated following intramuscular and oral administration methods to evaluate the safety for clinical use.Six healthy native dogs at a single dosage of 2.75 mg per kg body weight were chosen by this crossover design trial.Marbofloxacin concentration in plasma was determined by a high performance liquid chromatography with inner standard method.The parameters were concluded by 3P97 computer program.The concentration-time data were both fitted a one-compartment open model after intramuscular and oral administration of marbofloxacin.The main pharmacokinetic parameters were as follows:T_(1/2ka) (0.52±0.41) h and (0.41±0.13) h,T_(1/2ke) (4.40±1.86) h and (6.25±1.80) h,T_(peak) (1.53±0.75) h and (1.68±0.39) h,C_(max)(1.36±0.38) μg/mL and (0.93±0.06) μg/mL,AUC (10.64±2.66) (μg·h)/mL and (8.68±1.98) (μg·h)/mL,respectively for intramuscular and oral administration.The results showed that the pharmacokinetic characteristics of marbofloxacin in healthy dogs manifested the rapid absorption,big apparent volume of distribution,slow elimination.And oral adminstration showed more wide and deep tissue distribution than intramuscular adminstation.