CAJ | 학술논문

Numb是生物体内重要的细胞命运决定因子之一,不仅对神经系统的发育起着关键性的作用,与肿瘤的发生也密切相关.Numb 通过影响细胞分裂方式、细胞极性、上皮间质转化等过程,通过对Notch、p53、Hg 等重要信号通路的调节影响肿瘤的形成、浸润与转移.Numb 表达水平与肿瘤疾病的恶性程度及预后密切相关,探索Numb在肿瘤中的作用对今后将Numb 作为肿瘤治疗的新靶点具有重要意义.
Numb시생물체내중요적세포명운결정인자지일,불부대신경계통적발육기착관건성적작용,여종류적발생야밀절상관.Numb 통과영향세포분렬방식、세포겁성、상피간질전화등과정,통과대Notch、p53、Hg 등중요신호통로적조절영향종류적형성、침윤여전이.Numb 표체수평여종류질병적악성정도급예후밀절상관,탐색Numb재종류중적작용대금후장Numb 작위종류치료적신파점구유중요의의.
Numb,one of the important cell fate determinants,plays a key role in regulation of nerve system development,and it is closely related to the occurrence of tumors.It is proven that Numb is implicated in the processes of occurrence,invasion and metastasis of tumors through regulating the way of cell division,cell polarity,epithelial-mesenchymal transitions and several signal pathways,e.g.,Notch,Hh,p53.The expression levels of Numb in cells are related to the malignant degree and prognosis of tumors.It is vital to explore the role of Numb in tumors for treating tumors at the standpoint of Numb.