CAJ | 학술논문

目的探讨抗抑郁治疗对稳定期慢性阻塞性肺疾病合并抑郁患者的生存质量的影响.方法 43例稳定期慢性阻塞性肺疾病合并抑郁患者随机分为治疗组(n=22)和对照组(n=21),对照组按稳定期慢性阻塞性肺疾病患者常规扩张支气管、化痰等治疗;治疗组在对照组基础上口服舍曲林50 mg,1次/d,疗程6周、10周.测定治疗前后肺功能、营养指标及进行生存质量评分.结果治疗组治疗前后的肺功能、营养指标及生存质量评分差异有统计学意义(P<0.05,P<0.01),对照组差异无统计学意义(P>0.05).结论抗抑郁治疗对于提高慢性阻塞性肺疾病稳定期合并抑郁患者生存质量有重要意义.
목적 탐토항억욱치료대은정기만성조새성폐질병합병억욱환자적생존질량적영향.방법 43례은정기만성조새성폐질병합병억욱환자수궤분위치료조(n=22)화대조조(n=21),대조조안은정기만성조새성폐질병환자상규확장지기관、화담등치료;치료조재대조조기출상구복사곡림50 mg,1차/d,료정6주、10주.측정치료전후폐공능、영양지표급진행생존질량평분.결과 치료조치료전후적폐공능、영양지표급생존질량평분차이유통계학의의(P<0.05,P<0.01),대조조차이무통계학의의(P>0.05).결론 항억욱치료대우제고만성조새성폐질병은정기합병억욱환자생존질량유중요의의.
Objective To study the effects of antidepressant treatment on living quality of patients at stable stage of COPD with depression. Methods 43 cases at stable stage of COPD with depression were randomly divided into treatment group( n = 22) and control group( n = 21 ). The control group were given appropriate bronchodilators and disperse phlegm with common;the treatment group were given zoleft(50mg, 1 time/d, 6 weeks and 10 weeks) based on the control group. Lung function, nutritional status and quality of life score before and after inpatient treat-ment were determined. Results There was significant difference on lung function, nutritional status and quality of life score between the treatment group before and after inpatient treatment( P < 0.05 ～ P < 0.01 ). There was no significant difference in the control group (P > 0.05 ). Conclusion Antidepressant treatment on patients at stable stage of COPD with depression is very important for improving the quality of life.