CAJ | 학술논문

目的探讨轻度胃肠炎伴婴幼儿惊厥常见感染病原及轮状病毒(RV)、诺沃克病毒(NoV)导致惊厥发生的差异.方法用RT-PCR方法对30例轻度胃肠炎伴婴幼儿惊厥患儿的大便及脑脊液中RV、NoV进行检测,分析两种病毒所导致惊厥发作频率的差异.结果 30例中,RV粪便阳性17例(56.7%),脑脊液阳性3例(17.7%);NoV粪便阳性6例(25.0%),脑脊液阳性1例(16.7%).NoV感染患儿惊厥的发生次数为(4.33±1.75)次,明显高于RV感染患儿[(2.53±1.12)次],差异有非常显著性(P＜0.01).脑脊液中病毒阳性患儿的惊厥发生次数为(4.75±1.71)次,明显高于阴性患儿[(2.63±1.21)次](P＜0.01).结论 RV、NoV是导致轻度胃肠炎伴婴幼儿惊厥的常见病原;NoV感染对中枢神经系统的影响程度可能大于RV感染;脑脊液中病毒存在可能与惊厥的频繁发生有关,其具体机制有待进一步研究.
목적 탐토경도위장염반영유인량궐상견감염병원급륜상병독(RV)、낙옥극병독(NoV)도치량궐발생적차이.방법 용RT-PCR방법대30례경도위장염반영유인량궐환인적대편급뇌척액중RV、NoV진행검측,분석량충병독소도치량궐발작빈솔적차이.결과 30례중,RV분편양성17례(56.7%),뇌척액양성3례(17.7%);NoV분편양성6례(25.0%),뇌척액양성1례(16.7%).NoV감염환인량궐적발생차수위(4.33±1.75)차,명현고우RV감염환인[(2.53±1.12)차],차이유비상현저성(P＜0.01).뇌척액중병독양성환인적량궐발생차수위(4.75±1.71)차,명현고우음성환인[(2.63±1.21)차](P＜0.01).결론 RV、NoV시도치경도위장염반영유인량궐적상견병원;NoV감염대중추신경계통적영향정도가능대우RV감염;뇌척액중병독존재가능여량궐적빈번발생유관,기구체궤제유대진일보연구.
Objective To explore the common pathogen of infantile convulsions associated with mild gastroenteritis, and to study the differences between the seizures caused by the two kinds of virus.Methods RT-PCR was used to detect Rotavirus (RV) and Norwalkvirus (NoV) in stool and cerebrospinal fluid of 30 cases with infantile convulsions associated with mild gastroenteritis. The differences between the frequency of seizures caused by two kinds of virus were analyzed by statistical methods (two-sample t-test).Results 17/30 (56. 7%) were RV-positive in stool and 3/17 (17. 7%) in cerebrospinal fluid; 6/30 (25.0%) were NoV-positive in stool and 1/6 (16. 7%) in cerebrospinal fluid. The seizure frequency with NoV infection was (4. 33 ± 1.75) times, and RV infection patients was (2. 53 ± 1.12) times (P ＜ 0. 01).The seizure frequency of CSF virus-positive children was (4. 75 ± 1.71) times compared to (2. 63 ± 1.21)times in virus-negative children (P ＜ 0.01). Conclusion The common pathogens causing infantile convulsions associated with mild gastroenteritis were RV and NoV. The degree of NoV infection affecting the central nervous system may be greater than RV. The presence of the virus in cerebrospinal fluid may lead to higher incidence of seizures,but their exact roles related to the occurrence of seizures remain to be further studied.