CAJ | 학술논문

目的采用基于体素的分析方法(VBA)前瞻性研究阿尔茨海默病(AD)患者扩散张量成像(DTI)表观扩散系数(ADC)和各向异性分数(FA)在体素水平上与简易智能状态检查(MMSE)评分的相关性. 方法 12例AD患者,平均年龄(70.0±10.5)岁和16例正常志愿者,平均年龄(66.5±6.7)岁,采用平面回波扩散序列和32通道线圈采集扩散张量数据获得ADC和FA图像.VBA观察AD患者ADC、FA值改变与神经心理学相关性. 结果 AD患者双侧颞叶、双侧前扣带束ADC值增高,FA值减低,左侧颞叶、左侧前扣带束ADC值增高和FA值减低范围大于右侧；AD患者双侧后扣带回ADC值增加,FA值无阈上差别；ADC值增高范围大于FA值减低范围.AD患者MMSE评分与右侧海马ADC值呈负相关(r=-0.9474,P=0.0232),与右侧海马FA值呈正相关趋势(r=0.5414,P=0.5853). 结论 AD患者右侧颞叶病变程度和范围小于左侧,扩散张量成像ADC值优于FA值,与AD患者智能异常具有更密切的关系.
목적 채용기우체소적분석방법(VBA)전첨성연구아이자해묵병(AD)환자확산장량성상(DTI)표관확산계수(ADC)화각향이성분수(FA)재체소수평상여간역지능상태검사(MMSE)평분적상관성. 방법 12례AD환자,평균년령(70.0±10.5)세화16례정상지원자,평균년령(66.5±6.7)세,채용평면회파확산서렬화32통도선권채집확산장량수거획득ADC화FA도상.VBA관찰AD환자ADC、FA치개변여신경심이학상관성. 결과 AD환자쌍측섭협、쌍측전구대속ADC치증고,FA치감저,좌측섭협、좌측전구대속ADC치증고화FA치감저범위대우우측；AD환자쌍측후구대회ADC치증가,FA치무역상차별；ADC치증고범위대우FA치감저범위.AD환자MMSE평분여우측해마ADC치정부상관(r=-0.9474,P=0.0232),여우측해마FA치정정상관추세(r=0.5414,P=0.5853). 결론 AD환자우측섭협병변정도화범위소우좌측,확산장량성상ADC치우우FA치,여AD환자지능이상구유경밀절적관계.
Objective To investigate the voxel-based correlation of mini-mental state examination(MMSE) score with apparent diffusion coefficients(ADC) and fractional anisotropy (FA) derived from diffusion tensor imaging(DTI) in the patients with Alzheimer disease. Methods 12 patients aged (70.0± 10.5) years and 16 normal control aged (66.5±6.7) years were enrolled in this study.DTI was performed based on sequence and 32-channel head coils.ADC and FA images were calculated and normalized to the same space and smoothed with 8 mm Gaussian Kernel. With statistical parameter mapping software SPM5 package,the independent two sample t-test with general linear model were performed to detect ADC and FA differences between AD patients and normal control.Correlation analysis was performed between MMSE score and FA or ADC. Results AD patients showed elevated ADC value and decreased FA value in bilateral temporal lobe and anterior cingulate,which was more pronounced in the left than in the right.There was elevation of ADC value but no FA decrease in bilateral posterior cingulate.The abnormal ADC area was larger than that of FA.There was negative correlation between MMSE score and ADC of the right hippocampus(r=-0.9474,P=0.0232) and a tendency towards positive correlation between MMSE score and FA of the right hippocampus(r=0.5414,P=0.5853). Conclusions ADC value may be more sensitive than FA value in DTI. Right temporal lobe microstructure involvement is less severe,but has a stronger relationship with neuropsyehological abnormality.